Evidence map›Paper›PMID 34016955›Full record

ArticleTranslational psychiatry2021

Opposite alterations of 5-HT

Rebeca Diez-Alarcia, Carolina Muguruza, Guadalupe Rivero, Aintzane García-Bea, Vanessa Gómez-Vallejo, Luis F Callado, Jordi Llop, Abraham Martín, J Javier Meana

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Cortical 5-HTMolecular psychiatry · 2025
    Pooled it
  2. Psilocybin restores behavior and 5-HTCell reports. Medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The crosstalk between 5-HTNeuropharmacology · 2023
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rebeca Diez-AlarciaDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-0806-9825
Carolina MuguruzaDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-0477-5757
Guadalupe RiveroDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-2537-4047
Aintzane García-BeaDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.
Vanessa Gómez-VallejoCIC BiomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia/San Sebastian, Spain.
Luis F CalladoDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0001-9941-012X
Jordi LlopCIC BiomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia/San Sebastian, Spain.
Abraham MartínAchucarro Basque Center for Neuroscience, Leioa, Bizkaia, Spain.
J Javier MeanaDepartment of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain. javier.meana@ehu.eus.ORCID http://orcid.org/0000-0002-7913-6714
University of the Basque Country · ESCIC biomaGUNE · ESIkerbasque · ES

Funding

EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) 747487Eusko Jaurlaritza (Basque Government) IT-1211-19Eusko Jaurlaritza (Basque Government) SAIOTEK S-PE13UN019Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) CTQ-2017-87637-R),Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) MDM-2017-0720Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) SAF-2009-08460Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) SAF-2017-88126-R
6 · The paper itself

Abstract

The status of serotonin 5-HT

Indexed as

Antipsychotic AgentsSchizophreniaBrainHumansReceptor, Serotonin, 5-HT2ASerotoninAntipsychotic AgentsReceptor, Serotonin, 5-HT2ASerotonin

Identifiers

PMID34016955
PMCPMC8137947
OpenAlexW3163918973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.