Evidence map›Paper›PMID 34016897›Full record

ArticlePancreas

Blood Leukocyte Signaling Pathways as Predictors of Severity of Acute Pancreatitis.

Antti Turunen, Antti Kuuliala, Harri Mustonen, Pauli Puolakkainen, Leena Kylänpää, Krista Kuuliala

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Circulating Markers of Necroptosis in Acute Pancreatitis.Digestive diseases and sciences · 2024
    Article
  5. Circulating monocytes in acute pancreatitis.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Antti TurunenFrom the Abdominal Center, Department of Abdominal Surgery.
Antti KuulialaBacteriology and Immunology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Harri MustonenFrom the Abdominal Center, Department of Abdominal Surgery.
Pauli PuolakkainenFrom the Abdominal Center, Department of Abdominal Surgery.
Leena KylänpääFrom the Abdominal Center, Department of Abdominal Surgery.
Krista KuulialaBacteriology and Immunology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Urology Team · USHelsinki University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesClinical practice lacks biomarkers to predict the severity of acute pancreatitis (AP). We studied if intracellular signaling of circulating leukocytes could predict persistent organ dysfunction (OD) and secondary infections in AP.

methodsA venous blood sample was taken from 174 patients with AP 72 hours or less from onset of symptoms and 31 healthy controls. Phosphorylation levels (p) of appropriately stimulated signal transducer and activator of transcription 1 (STAT1), STAT6, nuclear factor-κB (NF-κB), Akt, and nonstimulated STAT3 in monocytes, neutrophils, and lymphocytes was measured using phosphospecific flow cytometry.

resultsThe patients showed higher pSTAT3 and lower pSTAT1, pSTAT6, pNF-κB, and pAkt than healthy controls. pSTAT3 in all leukocyte subtypes studied increased, and pSTAT1 in monocytes and T cells decreased in an AP severity-wise manner. In patients without OD at sampling, high pSTAT3 in monocytes and T lymphocytes were associated with development of persistent OD. In patients with OD, low interleukin-4-stimulated pSTAT6 in monocytes and neutrophils and Escherichia coli-stimulated pNF-κB in neutrophils predicted OD persistence. High pSTAT3 in monocytes, CD8+ T cells, and neutrophils; low pSTAT1 in monocytes and T cells; and low pNF-κB in lymphocytes predicted secondary infections.

conclusionsLeukocyte STAT3, STAT1, STAT6, and NF-κΒ phosphorylations are potential predictors of AP severity.

Indexed as

Signal TransductionAdultAgedAged, 80 and overBiomarkersCase-Control StudiesFemaleFlow CytometryHumansLeukocytesMaleMiddle AgedNF-kappa BPancreatitisPhosphorylationPredictive Value of TestsBiomarkersNF-kappa BSTAT1 protein, humanSTAT1 Transcription FactorSTAT3 protein, humanSTAT3 Transcription FactorSTAT6 protein, humanSTAT6 Transcription FactorSTAT Transcription Factors

Identifiers

PMID34016897
PMCPMC8195735
OpenAlexW3160089959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.