Evidence map›Paper›PMID 34016890›Full record

ArticlePancreas

Identification of a Risk Profile for New-Onset Diabetes After Acute Pancreatitis.

Stephen A Firkins, Phil A Hart, Georgios I Papachristou, Luis F Lara, Zobeida Cruz-Monserrate, Alice Hinton, Darwin L Conwell, David P Bradley, Somashekar G Krishna

Open access · greenAbstract read
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Approach to the Patient With Pancreatogenic Diabetes.The Journal of clinical endocrinology and metabolism · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Diabetes as a consequence of acute pancreatitis.World journal of gastroenterology · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stephen A FirkinsFrom the Department of Internal Medicine.
Phil A HartDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
Georgios I PapachristouDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
Luis F LaraDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
Zobeida Cruz-MonserrateDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
Alice HintonDivision of Biostatistics, College of Public Health, The Ohio State University.
Darwin L ConwellDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
David P BradleyDivision of Endocrinology and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH.
Somashekar G KrishnaDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
NIDDK NIH HHS U01 DK108327
6 · The paper itself

Abstract

objectivesThere is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM.

methodsThe Nationwide Readmissions Database (2010-2014) was used to identify all nondiabetic adults with an index primary diagnosis of AP. Multiple exclusions were applied to identify cohorts with and without AP-related DM. A case-control study was conducted to identify risk factors for developing AP-related DM within the calendar year.

resultsWe identified 2510 subjects with AP-related DM and 40,308 controls with AP who did not develop DM. Multivariable analysis revealed that increasing age (50-64 years; adjusted odds ratio [aOR], 1.35; 95% confidence interval [CI], 1.14-1.60), male sex (aOR, 1.2; 95% CI, 1.03-1.40), lowest income quartile (aOR, 1.48; 95% CI, 1.18-1.84), Elixhauser comorbidity index of 3 or higher (aOR, 1.47; 95% CI, 1.23-1.75), components of metabolic syndrome (aOR, 2.12; 95% CI, 1.21-3.70), severe AP (aOR, 1.60; 95% CI, 1.34-1.90), and recurrent AP (aOR, 1.46; 95% CI, 1.24-1.72) were independently associated with increased risk of AP-related DM.

conclusionsThese population-level variables predictive of developing AP-related DM can potentially identify patients who may benefit from closer follow-up, intensive education, and implementation of preventative strategies.

Indexed as

AdolescentAdultAgedComorbidityDatabases, FactualDiabetes MellitusFemaleHumansMaleMiddle AgedPancreatitisPatient ReadmissionPrognosisRecurrenceRetrospective StudiesRisk Assessment

Identifiers

PMID34016890
PMCPMC8486922
OpenAlexW3163773518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.