Evidence map›Paper›PMID 34016690›Full record

ArticleGenes & development2021

Small RNAs guide histone methylation in

Jean-Sébastien Parent, Jonathan Cahn, Rowan P Herridge, Daniel Grimanelli, Robert A Martienssen

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Jean-Sébastien ParentHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.ORCID 0000-0001-7859-7415
Jonathan CahnHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Rowan P HerridgeHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Daniel GrimanelliCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Robert A MartienssenHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Howard Hughes Medical Institute · USAgriculture and Agri-Food Canada · CACentre de Coopération Internationale en Recherche Agronomique pour le Développement · FR

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Transposons, RNA Interference and HeterochromatinR01GM067014 · NIGMS · COLD SPRING HARBOR LABORATORY · PI MARTIENSSEN, ROBERT A · 2003 to 2016
$4.1M
NCI NIH HHS P30 CA045508NIGMS NIH HHS R01 GM067014
6 · The paper itself

Abstract

Epigenetic reprogramming occurs during gametogenesis as well as during embryogenesis to reset the genome for early development. In flowering plants, many heterochromatic marks are maintained in sperm, but asymmetric DNA methylation is mostly lost. Asymmetric DNA methylation is dependent on small RNA but the re-establishment of silencing in embryo is not well understood. Here we demonstrate that small RNAs direct the histone H3 lysine 9 dimethylation during

Indexed as

ArabidopsisArabidopsis ProteinsDNA MethylationEpigenesis, GeneticGene SilencingHistonesRNA, PlantSeedsArabidopsis ProteinsHistonesRNA, PlantSUVH9 protein, ArabidopsisDNA methylationepigenetic reprogramminghistone methylationplant embryogenesissmall RNA molecules

Identifiers

PMID34016690
PMCPMC8168562
OpenAlexW3160971999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.