Evidence map›Paper›PMID 34016574›Full record

ArticleThe British journal of ophthalmology2022

Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study.

Ming Ming Zhu, Bonnie N K Choy, Qi Sheng You, Jonathan Cheuk Hung Chan, Alex L K Ng, Kendrick Shih, Janice Jing Chee Cheung, Jasper Ka Wai Wong, Jennifer Shum, Michael Y Ni and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The British journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Vascular density normative data of radial peripapillary capillary plexus in healthy Caucasian subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  3. Article
  4. Observational
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Ming Ming Zhu *Ophthalmology, University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0003-0221-2325
Bonnie N K Choy *Ophthalmology, University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0002-9740-3935
Qi Sheng YouOregon Health & Science University Casey Eye Institute, Portland, Oregon, USA.
Jonathan Cheuk Hung ChanOphthalmology, University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong.ORCID 0000-0002-0177-8178
Alex L K NgOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0002-8321-5634
Kendrick ShihOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.
Janice Jing Chee CheungOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0003-1216-729X
Jasper Ka Wai WongOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0003-4039-5468
Jennifer ShumOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.
Michael Y NiSchool of Public Health, University of Hong Kong, Hong Kong, Hong Kong.
Jimmy Shiu-Ming LaiOphthalmology, University of Hong Kong, Hong Kong, Hong Kong.
Gabriel M LeungSchool of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Ian Y WongOphthalmology, University of Hong Kong, Hong Kong, Hong Kong ianyhwong@gmail.com.ORCID 0000-0002-5328-1796
University of Hong Kong · HKChinese University of Hong Kong · HKKwong Wah Hospital · CNOregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the optic disc and peripapillary vessel density, as well as its ocular and systemic associations, in healthy eyes among adult Chinese population.

methodsA population-based cross-sectional eye survey was conducted on Chinese adults residing in Hong Kong. 1891 eyes from 1891 participants who completed 4.5×4.5 mm optical coherence tomography angiography scans were recruited. Among the 1891 eyes, 404 were excluded due to low scan quality, optic disc or retinal disorders and non-Chinese ethnicity. The vessel densities (VDs) at nerve fibre layer plexus (NFLP) at both optic disc and peripapillary were collected for analysis. Multiple linear regression analysis was performed to determine the ocular and systemic associations of NFLP VD.

resultsThe study included 1487 participants (men: 41.2%) with a mean age of 48.8±15.4 years. The mean NFLP VD of the whole

conclusionsThis large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD.

Indexed as

Optic DiskAdultCross-Sectional StudiesFluorescein AngiographyHumansIntraocular PressureMaleMiddle AgedRetinal VesselsTomography, Optical Coherenceepidemiologyglaucomaimagingoptic nerve

Identifiers

PMID34016574
PMCPMC9510412
OpenAlexW3163256055

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.