Evidence map›Paper›PMID 34016377›Full record

ArticleBiological psychiatry2021

Ketamine for a Boost of Neural Plasticity: How, but Also When?

Hao Wu, Neil K Savalia, Alex C Kwan

Abstract readComment
In one paragraph

Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Ketamine and Evolving Neuroplasticity.Clinical drug investigation · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Ketamine Reverses Chronic Stress-Induced Behavioral Changes via the Expression of CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Hao WuInterdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut.
Neil K SavaliaMedical Scientist Training Program, Yale University School of Medicine, New Haven, Connecticut.
Alex C KwanInterdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut. Electronic address: alex.kwan@yale.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
A Dendritic Substrate for Fast-Acting Antidepressant ActionR01MH121848 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2020 to 2024
$2.6M
Frontal cortical neural dynamics and chronic social stressR01MH112750 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2017 to 2021
$2.1M
NIGMS NIH HHS T32 GM007205NIMH NIH HHS R01 MH112750NIMH NIH HHS R01 MH121848
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

KetamineAntidepressive AgentsGlutamic AcidNeuronal PlasticityPrefrontal CortexAntidepressive AgentsGlutamic AcidKetamine

Identifiers

PMID34016377
PMCPMC8190578

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.