Evidence map›Paper›PMID 34016221›Full record

ArticleOncology research2022

Evaluation of

Rosa Della Monica, Mariella Cuomo, Roberta Visconti, Annabella di Mauro, Michela Buonaiuto, Davide Costabile, Giulia De Riso, Teodolinda Di Risi, Elia Guadagno, Roberto Tafuto and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Oncology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Prospective Evaluation ofCurrent oncology (Toronto, Ont.) · 2023
    Observational
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 5 countries.

Rosa Della MonicaCEINGE Biotecnologie AvanzateNaplesItaly.
Mariella CuomoCEINGE Biotecnologie AvanzateNaplesItaly.
Roberta ViscontiInstitute of Experimental Endocrinology and Oncology, Italian National Council of ResearchNaplesItaly.
Annabella di MauroDepartment of Pathology, National Cancer Institute, IRCCS-Foundation G. Pascale,NaplesItaly.
Michela BuonaiutoCEINGE Biotecnologie AvanzateNaplesItaly.
Davide CostabileCEINGE Biotecnologie AvanzateNaplesItaly.
Giulia De RisoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II,NaplesItaly.
Teodolinda Di RisiCEINGE Biotecnologie AvanzateNaplesItaly.
Elia GuadagnoDepartment of Advanced Biomedical Sciences, Section of Pathology, University of Naples Federico II,NaplesItaly.
Roberto TafutoDivision of Neurosurgery, University of Naples Federico II,NaplesItaly.
Sabrina LamiaS.C. Sarcomas and Rare Tumors, National Cancer Institute, IRCCS-Foundation G. Pascale,NaplesItaly.
Alessandro OttaianoDepartment of Abdominal Oncology, National Cancer Institute, IRCCS-Foundation G. Pascale,NaplesItaly.
Paolo CappabiancaDivision of Neurosurgery, University of Naples Federico II,NaplesItaly.
Maria Laura Del Basso de CaroDepartment of Advanced Biomedical Sciences, Section of Pathology, University of Naples Federico II,NaplesItaly.
Fabiana TatangeloDepartment of Pathology, National Cancer Institute, IRCCS-Foundation G. Pascale,NaplesItaly.
Juergen HenchInstitute for Medical Genetics and Pathology, Division of Neuropathology, University Hospital BaselBaselSwitzerland.
Stephan FrankInstitute for Medical Genetics and Pathology, Division of Neuropathology, University Hospital BaselBaselSwitzerland.
Salvatore TafutoS.C. Sarcomas and Rare Tumors, National Cancer Institute, IRCCS-Foundation G. Pascale,NaplesItaly.
Lorenzo ChiariottiCEINGE Biotecnologie AvanzateNaplesItaly.
Ceinge Biotecnologie Avanzate (Italy) · ITUniversity of Naples Federico II · ITCancer Institute (WIA) · INNational Cancer Institute · USInstitute of Experimental Endocrinology of the Slovak Academy of Sciences · SKNational Cancer Institute · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unresectable neuroendocrine neoplasms (NENs) often poorly respond to standard therapeutic approaches. Alkylating agents, in particular temozolomide, commonly used to treat high-grade brain tumors including glioblastomas, have recently been tested in advanced or metastatic NENs, where they showed promising response rates. In glioblastomas, prediction of response to temozolomide is based on the assessment of the methylation status of the

Indexed as

Antineoplastic Agents, AlkylatingBrain NeoplasmsDNA MethylationDNA Modification MethylasesDNA Repair EnzymesHumansPromoter Regions, GeneticTemozolomideTumor Suppressor ProteinsAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTemozolomideTumor Suppressor Proteins

Identifiers

PMID34016221
PMCPMC8790131
OpenAlexW3160626847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.