ArticleBMC microbiology2021
Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Trial
- Low Prevalence and Abundance ofMicroorganisms · 2026Article
- Species level composition of Faecalibacterium spp. in the gut of Japanese adults revealed by rpoA-based sequencing analysis.FEMS microbiology ecology · 2026Article
- Benefits of Regular Intake of Glucolacto-Oligosaccharides on Gut Health in Adults with Low Defecation Frequency: A Randomized, Double-Blind, Placebo-Controlled Study.Microorganisms · 2026Article
- Characterization of gut microbiota dysbiosis in breast cancer patients.Breast cancer (Tokyo, Japan) · 2026Article
- Intestinal microbiome gone native: gut microbiome shift and resistome diversity in first homecoming giant panda family.Frontiers in microbiology · 2026Article
- Dietary Effects, Age, and Urban-Rural Dynamics in Shaping Gut Microbiota of Elderly Vietnamese: A Cross-Sectional Study.Microorganisms · 2025Article
- From dysbiosis to longevity: a narrative review into the gut microbiome's impact on aging.Journal of biomedical science · 2025Review
- Trehalose improves growth performance and gut health of yellow-feathered broilers exposed to heat stress.Tropical animal health and production · 2025Article
- Article
- Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii.Microbiome · 2025Article
- Gut Microbiome Signatures in Multiple Sclerosis: A Case-Control Study with Machine Learning and Global Data Integration.Biomedicines · 2025Article
- NIBN Japan Microbiome Database, a database for exploring the correlations between human microbiome and health.Scientific reports · 2025Article
- Establishment of enterotype-specific antibodies for various diagnostic systems.Scientific reports · 2025Article
- Relationship Between Dietary Habits and Stress Responses Exerted by Different Gut Microbiota.Nutrients · 2025Article
- Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies.Journal of personalized medicine · 2025Review
- Anti-obesity peptides from food: Production, evaluation, sources, and commercialization.Comprehensive reviews in food science and food safety · 2025Review
- Gut microbiota heterogeneity in non-alcoholic fatty liver disease: a narrative review of drivers, mechanisms, and clinical relevance.Frontiers in microbiology · 2025Review
- Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study.Nutrition & metabolism · 2024Article
- The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study.BMC gastroenterology · 2024Article
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16 authors.
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Abstract
backgroundInter-individual variations in gut microbiota composition are observed even among healthy populations. The gut microbiota may exhibit a unique composition depending on the country of origin and race of individuals. To comprehensively understand the link between healthy gut microbiota and host state, it is beneficial to conduct large-scale cohort studies. The aim of the present study was to elucidate the integrated and non-redundant factors associated with gut microbiota composition within the Japanese population by 16S rRNA sequencing of fecal samples and questionnaire-based covariate analysis.
resultsA total of 1596 healthy Japanese individuals participated in this study via two independent cohorts, NIBIOHN cohort (n = 954) and MORINAGA cohort (n = 642). Gut microbiota composition was described and the interaction of these microorganisms with metadata parameters such as anthropometric measurements, bowel habits, medical history, and lifestyle were obtained. Thirteen genera, including Alistipes, Anaerostipes, Bacteroides, Bifidobacterium, Blautia, Eubacterium halli group, Faecalibacterium, Fusicatenibacter, Lachnoclostridium, Parabacteroides, Prevotella_9, Roseburia, and Subdoligranulum were predominant among the two cohorts. On the basis of univariate analysis for overall microbiome variation, 18 matching variables exhibited significant association in both cohorts. A stepwise redundancy analysis revealed that there were four common covariates, Bristol Stool Scale (BSS) scores, gender, age, and defecation frequency, displaying non-redundant association with gut microbial variance.
conclusionsWe conducted a comprehensive analysis of gut microbiota in healthy Japanese individuals, based on two independent cohorts, and obtained reliable evidence that questionnaire-based covariates such as frequency of bowel movement and specific dietary habit affects the microbial composition of the gut. To our knowledge, this was the first study to investigate integrated and non-redundant factors associated with gut microbiota among Japanese populations.
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