Evidence map›Paper›PMID 34015961›Full record

ArticleCNS oncology2021

Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma.

Kelly Chamberlin, Gregory Chamberlin, Katherine Saunders, Simon Khagi

Open access · goldAbstract readCase Reports
In one paragraph

Article in CNS oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Concurrent de novo glioblastoma and meningiomatosis: a case report and systematic review of clinical, molecular, and topographical characteristics.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelly ChamberlinDepartment of Neurosurgery, UNC Hospitals, Chapel Hill, NC 27514, USA.
Gregory ChamberlinDepartment of Pathology & Laboratory Medicine, UNC Hospitals, Chapel Hill, NC 27514, USA.ORCID 0000-0003-4306-3549
Katherine SaundersDepartment of Pathology & Laboratory Medicine, UNC Hospitals, Chapel Hill, NC 27514, USA.
Simon KhagiDepartment of Neurosurgery, UNC Hospitals, Chapel Hill, NC 27514, USA.
University of North Carolina Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary intracranial collision tumors are rare in patients without predisposing factors. We report such a case in a 42-year-old female who presented with headaches and altered mental status. Imaging revealed a single heterogeneous, rim-enhancing lesion in the left parieto-occipital periventricular region, involving the corpus callosum. Stereotactic biopsy demonstrated glioblastoma. Subsequent tumor resection showed histologic evidence of glioblastoma and meningioma. Next-generation sequencing was performed on both tumor components. The glioblastoma exhibited a

Indexed as

Brain NeoplasmsGlioblastomaMeningeal NeoplasmsMeningiomaAdultFemaleHigh-Throughput Nucleotide SequencingHomozygoteHumansMutationSequence Deletioncollision tumorCSMD3glioblastomameningiomanext-generation sequencingTAF1L

Identifiers

PMID34015961
PMCPMC8162195
OpenAlexW3163760946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.