Evidence map›Paper›PMID 34015766›Full record

ArticleAging2021

Silencing lncRNA AK136714 reduces endothelial cell damage and inhibits atherosclerosis.

Jing Bai, Jianxia Liu, Zexian Fu, Yuanyuan Feng, Bing Wang, Wenjuan Wu, Ruiying Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Role of LncRNAs in the Pathogenesis of Coronary Artery Disease.Reviews in cardiovascular medicine · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing BaiDepartment of Geriatrics, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Jianxia LiuDepartment of Nursing, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Zexian FuDepartment of Scientific Research and Education, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Yuanyuan FengDepartment of Stomatology, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Bing WangDepartment of Dynamic electrocardiogram, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Wenjuan WuDepartment of Breast, The Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Ruiying ZhangDepartment of Geriatrics, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei Province, China.
Hebei University of Engineering · CNAffiliated Hospital of Hebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis correlates with ischemic cardio-cerebrovascular diseases such as coronary heart disease. Long non-coding RNAs (lncRNAs) can promote atherosclerosis. We investigated the role of the lncRNA AK136714 in atherosclerosis. Compared with the healthy group, lncRNA AK136714 expression was elevated in the plaque and plasma of the atherosclerosis patients in a GEO dataset. AK136714 silencing inhibited atherosclerosis formation in ApoE-/- mice. AK136714 silencing also protected the endothelial barrier and inhibited endothelial cell inflammation.

Indexed as

Gene SilencingAnimalsApoptosisAtherosclerosisELAV-Like Protein 1Endothelial CellsForkhead Box Protein O3HumansHuman Umbilical Vein Endothelial CellsInflammationMaleMiceMice, Inbred C57BLPlaque, AtheroscleroticProtein BindingRNA, Long NoncodingELAV-Like Protein 1Forkhead Box Protein O3RNA, Long NoncodingAK136714atherosclerosisendothelial cellsFOXO3lncRNA

Identifiers

PMID34015766
PMCPMC8202876
OpenAlexW3162230421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.