Evidence map›Paper›PMID 34015676›Full record

ArticleEpidemics2021

Memory is key in capturing COVID-19 epidemiological dynamics.

Mircea T Sofonea, Bastien Reyné, Baptiste Elie, Ramsès Djidjou-Demasse, Christian Selinger, Yannis Michalakis, Samuel Alizon

Open access · goldAbstract read
In one paragraph

Article in Epidemics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  12. Epidemic models: why and how to use them.Anaesthesia, critical care & pain medicine · 2022
    Article
  13. Article
  14. Article
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  16. Epidemiological and clinical insights from SARS-CoV-2 RT-PCR crossing threshold values, France, January to November 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
  17. Article
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  20. Predicting COVID-19 incidence in French hospitals using human contact network analytics.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mircea T SofoneaMIVEGEC, Univ. Montpellier, CNRS, IRD, France. Electronic address: mircea.sofonea@umontpellier.fr.
Bastien ReynéMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Baptiste ElieMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Ramsès Djidjou-DemasseMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Christian SelingerMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Yannis MichalakisMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Samuel AlizonMIVEGEC, Univ. Montpellier, CNRS, IRD, France.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 virus has spread over the world rapidly creating one of the largest pandemics ever. The absence of immunity, presymptomatic transmission, and the relatively high level of virulence of the COVID-19 infection led to a massive flow of patients in intensive care units (ICU). This unprecedented situation calls for rapid and accurate mathematical models to best inform public health policies. We develop an original parsimonious discrete-time model that accounts for the effect of the age of infection on the natural history of the disease. Analysing the ongoing COVID-19 in France as a test case, through the publicly available time series of nationwide hospital mortality and ICU activity, we estimate the value of the key epidemiological parameters and the impact of lock-down implementation delay. This work shows that including memory-effects in the modelling of COVID-19 spreading greatly improves the accuracy of the fit to the epidemiological data. We estimate that the epidemic wave in France started on Jan 20 [Jan 12, Jan 28] (95% likelihood interval) with a reproduction number initially equal to 2.99 [2.59, 3.39], which was reduced by the national lock-down started on Mar 17 to 24 [21, 27] of its value. We also estimate that the implementation of the latter a week earlier or later would have lead to a difference of about respectively -13k and +50k hospital deaths by the end of lock-down. The present parsimonious discrete-time framework constitutes a useful tool for now- and forecasting simultaneously community incidence and ICU capacity strain.

Indexed as

Basic Reproduction NumberCommunicable Disease ControlCOVID-19Epidemiological MonitoringForecastingFranceHospital MortalityHumansIncidenceIntensive Care UnitsModels, TheoreticalSARS-CoV-2Discrete-time modellingEpidemiosurveillanceMathematical epidemiologyNon-Markovian processesReproduction number

Identifiers

PMID34015676
PMCPMC8076764
OpenAlexW3158990692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.