Evidence map›Paper›PMID 34015624›Full record

ArticleJournal of affective disorders2021

Risk factors for pre-adolescent onset suicidal behavior in a high-risk sample of youth.

Jamie Zelazny, Barbara Stanley, Giovanna Porta, J John Mann, Maria Oquendo, Boris Birmaher, Nadine Melhem, David A Brent

Open access · bronzeAbstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jamie ZelaznyUniversity of Pittsburgh, Western Psychiatric Hospital, Pittsburgh PA. Electronic address: jmz22@pitt.edu.
Barbara StanleyColumbia University, New York State Psychiatric Institute, New York, New York.
Giovanna PortaUniversity of Pittsburgh, Western Psychiatric Hospital, Pittsburgh PA.
J John MannColumbia University, New York State Psychiatric Institute, New York, New York.
Maria OquendoUniversity of Pennsylvania, Philadelphia, PA.
Boris BirmaherUniversity of Pittsburgh, Western Psychiatric Hospital, Pittsburgh PA.
Nadine MelhemUniversity of Pittsburgh, Western Psychiatric Hospital, Pittsburgh PA.
David A BrentUniversity of Pittsburgh, Western Psychiatric Hospital, Pittsburgh PA.
University of Pittsburgh · USNew York Psychoanalytic Society and Institute · USUniversity of Pennsylvania · US

Funding

CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Familial Pathways to Early-Onset Suicide AttemptsR01MH056612 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRENT, DAVID A. · 2002 to 2013
$5.4M
Familial Pathways to Early-OnSet Suicide AttemptsR01MH056390 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2002 to 2013
$4.5M
FAMILIAL PATHWAYS TO EARLY ONSET SUICIDE ATTEMPTSR10MH056390 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI MANN, JOSEPH J · 1997 to 2001
$1.1M
FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTSR10MH056612 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRENT, DAVID A. · 1997 to 2001
$824k
NIMH NIH HHS R01 MH056390NIMH NIH HHS R01 MH056612NIMH NIH HHS R10 MH056390NIMH NIH HHS R10 MH056612NIMH NIH HHS T32 MH018951
6 · The paper itself

Abstract

objectiveTo identify risk factors for preadolescent onset suicidal behavior compared with adolescent/young adult onset suicidal behavior in a longitudinal sample of youth with parental history of mood disorders.

methodsThe sample includes 545 youth who were age 21 years or less at the time of their baseline assessment. Participants underwent baseline and yearly study assessments. Observations were censored at the time point closest to the first episode of suicidal behavior for youth with suicidal behavior and at the time of last observation for youth without suicidal behavior. Youth were categorized into 3 groups: first onset of suicidal behavior before the age of 13 (n = 32), first onset of suicidal behavior between the ages of 13-21 (n = 51) and those without suicide related behaviors (n = 462). ANOVA, Chi-square, Fisher's exact test and multinomial regression were used to test the hypotheses.

resultsSignificant predictors of preadolescent onset suicidal behavior were diagnosis of depressive disorder (RRR = 11.41, p<.001) and diagnosis of ADHD (RRR = 2.86, p = .02). Adolescent onset was predicted by diagnosis of depressive disorder (RRR = 4.12, p = .008), female sex (RRR = 2.68, p = .02) and self-reported suicidal ideation (RRR = 1.48, p = .004). LIMITATIONS: These results are most applicable to offspring of parents with significant mood disorders.

conclusionsThe strongest predictor of suicidal behavior in both groups was a diagnosis of depressive disorder, and the risk was nearly 3 times higher in preadolescents. ADHD was a significant predictor only for preadolescents, while female sex and self-reported suicidal ideation predicted suicidal behavior in adolescents.

Indexed as

Adolescent BehaviorSuicidal IdeationAdolescentAdultFemaleHumansMood DisordersRisk FactorsSuicide, AttemptedYoung AdultAdolescentsChildrenRisk factorsSuicidal behavior

Identifiers

PMID34015624
PMCPMC8223608
OpenAlexW3158281091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.