Evidence map›Paper›PMID 34015515›Full record

SynthesisThe Journal of surgical research2021

Age-Related Risk Factors in Ventral Hernia Repairs: A Review and Call to Action.

Julia Hamilton, Bradley Kushner, Sara Holden, Timothy Holden

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in The Journal of surgical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. The prehabilitation paradox in ventral hernia: from universal to personalized care.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Impact of glucagon-Like peptide-1 agonists in optimizing abdominal wall Reconstruction patients.Hernia : the journal of hernias and abdominal wall surgery · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Long-term reoperation rate following primary ventral hernia repair: a register-based study.Hernia : the journal of hernias and abdominal wall surgery · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Julia HamiltonDepartment of Surgery, Washington University School of Medicine. St. Louis, Missouri. Electronic address: juliahamilton@wustl.edu.
Bradley KushnerDepartment of Surgery, Washington University School of Medicine. St. Louis, Missouri.
Sara HoldenDepartment of Surgery, Washington University School of Medicine. St. Louis, Missouri.
Timothy HoldenDepartment of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, Missouri.
Washington University in St. Louis · US

Funding

SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007815 · NHLBI · WASHINGTON UNIVERSITY · PI CHUNG, KOONG-NAH · 1995 to 2020
$2.8M
NHLBI NIH HHS T35 HL007815
6 · The paper itself

Abstract

backgroundAs the population ages, the incidence of ventral hernias in older adults is increasing. Ventral hernia repairs (VHR) should not be considered low risk operations, particularly in older adults who are disproportionately affected by multiple age-related factors that can complicate surgery and adversely affect outcomes. Although age-related risk factors have been well established in other surgical fields, there is currently little data describing their impact on VHR.

methodsWe performed a systematic review of the literature to identify studies that examine the effects of age-related risk factors on VHR outcomes. This was conducted using Cochrane Library, Embase, PubMed (Medline), and Google Scholar databases, all updated through June 2020. We selected relevant studies using the keywords, multimorbidity, comorbidities, polypharmacy, functional dependence, functional status, frailty, cognitive impairment, dementia, sarcopenia, and malnutrition. Primary outcomes include mortality and overall complications following VHR.

resultsWe summarize the evidence basis for the significance of age-related risk factors in elective surgery and discuss how these factors increase the risk of adverse outcomes following VHR. In particular, we explore the impact of the following risk factors: multimorbidity, polypharmacy, functional dependence, frailty, cognitive impairment, sarcopenia, and malnutrition. As opposed to chronological age itself, age-related risk factors are more clinically relevant in determining VHR outcomes.

conclusionsGiven the increasing complexity of VHR, addressing age-related risk factors pre-operatively has the potential to improve surgical outcomes in older adults. Preoperative risk assessment and individualized prehabilitation programs aimed at improving patient-centered outcomes may be particularly useful in this population.

Indexed as

Age FactorsHernia, VentralHerniorrhaphyHumansPostoperative ComplicationsRisk FactorsTreatment OutcomeAgeFrailtyFunctional statusGeriatric syndromesPolypharmacyVentral hernia

Identifiers

PMID34015515
PMCPMC8338875
OpenAlexW3162188206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.