ReviewReproductive toxicology (Elmsford, N.Y.)2021
Placental outcomes of phthalate exposure.
Review in Reproductive toxicology (Elmsford, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Sex-dependent vulnerability to early-life phthalates exposure and autism spectrum disorders: a systematic review.Frontiers in child and adolescent psychiatry · 2026Pooled it
- Phthalate Exposures and Placental Health in Animal Models and Humans: A Systematic Review.Toxicological sciences : an official journal of the Society of Toxicology · 2022Pooled it
- Prenatal exposure to DEHTP replacement metabolites and odds of preeclampsia and gestational hypertension in a diverse nulliparous U.S. cohort.Environmental advances · 2026Article
- Associations of urinary phthalate metabolite and replacement chemical concentrations with gestational blood pressure.Journal of the Endocrine Society · 2026Article
- Prenatal Exposure to Mixtures of Nonpersistent Endocrine-Disrupting Chemicals and Angiogenic Biomarkers, Placental Function, and Fetal Growth.Environmental science & technology · 2026Article
- Associations of prenatal exposure to bisphenols and phthalates with the fetoplacental ratio in the New York University Children's Health and Environment Study (NYU CHES).Ecotoxicology and environmental safety · 2026Article
- Placental toxicity of alternative plasticizers: Current knowledge and future directions.Reproductive toxicology (Elmsford, N.Y.) · 2026Review
- Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.Journal of the Endocrine Society · 2026Article
- Prenatal phthalate exposure and neurodevelopmental delay in early childhood (1 to 3 years): An Environmental influences on Child Health Outcomes (ECHO) study.Environment international · 2026Article
- Editorial: Transgenerational effects of endocrine disrupting chemicals: unraveling hormonal and health impacts across generations.Frontiers in endocrinology · 2026Article
- Perinatal exposure to the environmental pollutant butyl benzyl phthalate (BBP) induces sex-specific alterations in the neuro-immune-endocrine network in adult rats.Frontiers in immunology · 2026Article
- Heavy metals detected in fetal and placental tissues in a pregnancy complicated by severe fetal growth impairment and sacrococcygeal teratoma: a case report.Frontiers in toxicology · 2026Article
- Association of in utero exposure to phthalate and DINCH metabolites with placental DNA methylation.Environment international · 2025Article
- Assessment of cat exposure to phthalates through phthalate metabolites analysis in the hair samples.Scientific reports · 2025Article
- Association of Exposure to Phthalate Metabolites with Antenatal Depression in US Pregnant Women.Toxics · 2025Article
- Biodegradation of phthalates DIBP, DMP, and DEP by Paenarthrobacter sp. strain PH1 - analysis of degradation, pathway, and its bioremediation potentiality in soil microcosm.World journal of microbiology & biotechnology · 2025Article
- Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs.Journal of hepatology · 2025Article
- Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts.Environment international · 2025Article
- The anti-inflammatory effect of the amniotic PPARγ pathways is not dysregulated by the alternative plasticizer DINCH and its metabolite MINCH in human fetal membranes.Environmental science and pollution research international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Proper placental development and function relies on hormone receptors and signaling pathways that make the placenta susceptible to disruption by endocrine disrupting chemicals, such as phthalates. Here, we review relevant research on the associations between phthalate exposures and dysfunctions of the development and function of the placenta, including morphology, physiology, and genetic and epigenetic effects. This review covers in vitro studies, in vivo studies in mammals, and studies in humans. We also discuss important gaps in the literature. Overall, the evidence indicates that toxicity to the placental and maternal-fetal interface is associated with exposure to phthalates. Further studies are needed to better elucidate the mechanisms through which phthalates act in the placenta as well as additional human studies that assess placental disruption through pregnancy with larger sample sizes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.