ArticleNeurobiology of learning and memory2021
Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats.
Article in Neurobiology of learning and memory, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response.Nature communications · 2026Article
- Devaluation of response-produced safety signals reveals circuits for goal-directed versus habitual avoidance in dorsal striatum.Nature communications · 2026Article
- Review
- New Insights into Potential Anti-Aging and Fatigue Effects of a Dietary Supplement from the Resveratrol Beverage in Aged SAMP8 Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.Behavioural brain research · 2024Article
- Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats.Neurobiology of stress · 2024Review
- Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats.bioRxiv : the preprint server for biology · 2024Article
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.bioRxiv : the preprint server for biology · 2024Article
- Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.Frontiers in behavioral neuroscience · 2024Article
- Experiences Shape Hippocampal Neuron Morphology and the Local Levels of CRHR1 and OTR.Cellular and molecular neurobiology · 2023Article
- Post-encounter freezing during approach-avoidance conflict: the role of the hippocampus.Nature reviews. Neuroscience · 2023Article
- Linking external stimuli with internal drives: A role for the ventral hippocampus.Current opinion in neurobiology · 2022Review
- Conditional Control of Instrumental Avoidance by Context Following Extinction.Frontiers in behavioral neuroscience · 2021Article
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Authors and funding
6 authors.
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Abstract
Considerable work indicates that instrumental responding is context-dependent, but the neural mechanisms underlying this phenomenon are poorly understood. Given the important role for the hippocampal formation in contextual processing, we hypothesized that reversible inactivation of the hippocampus would impair the context-dependence of active avoidance. To test this hypothesis, we used a two-way signaled active avoidance (SAA) task that requires rats to shuttle across a divided chamber during a tone CS in order to avoid a footshock US. After training, avoidance responding was assessed in an extinction test in both the training context and a novel context in a counterbalanced order. Rats performed significantly more avoidance responses in the training context than in the novel context, demonstrating the context-dependence of shuttle avoidance behavior. To examine the role of the hippocampus in the context-dependence of SAA, we reversibly inactivated either the dorsal (DH) or ventral hippocampus (VH) prior to testing. Inactivation of the VH eliminated the context-dependence of SAA and elevated avoidance responding in the novel context to levels similar to that expressed in the training context. In contrast, DH inactivation had no effect on avoidance in either context, and neither manipulation affected freezing behavior. Therefore, the integrity of the VH, but not DH, is required for the expression of the context-dependence of avoidance behavior.
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