ArticleAmerican journal of respiratory and critical care medicine2021
Micro-Computed Tomography Analysis of the Human Tuberculous Lung Reveals Remarkable Heterogeneity in Three-dimensional Granuloma Morphology.
Open access · hybridAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Computer vision applications for the detection or analysis of tuberculosis using digitised human lung tissue images - a systematic review.BMC medical imaging · 2024Pooled it
- NETosis associates with human TB lung tissue destruction and disease pathogenesis.EMBO molecular medicine · 2026Article
- Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.bioRxiv : the preprint server for biology · 2026Article
- The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis.The Journal of infectious diseases · 2026Review
- Mouse models of tuberculosis uniformly featuring hypoxic necrotic lesions and poor response to chemotherapy.Infection and immunity · 2026Article
- Genome-wide transcriptional landscape ofFrontiers in immunology · 2026Article
- Methodology for a freshly engineered or cryo-preserved 3D tuberculoma bioplatform for studying tuberculosis biology and high-content screening of therapeutics.Frontiers in immunology · 2026Article
- Levofloxacin-Catalase-PLGA Nanoparticles Potentiate Sonodynamic Therapy to Alleviate BCG-Induced Tuberculous Granulomas via PI3K/Akt/VEGF Pathway Suppression in Rats.International journal of nanomedicine · 2026Article
- Mouse Models Uniformly Featuring Human-like Lesions Harboring Drug-tolerantbioRxiv : the preprint server for biology · 2025Article
- Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization.PLoS pathogens · 2025Article
- The Kinetics of Bedaquiline Diffusion in Tuberculous Cavities Open a Window for the Emergence of Resistance.The Journal of infectious diseases · 2025Article
- Article
- Correlative 3D imaging method for analysing lesion architecture in susceptible mice infected with Mycobacterium tuberculosis.Disease models & mechanisms · 2025Article
- How macrophage heterogeneity affects tuberculosis disease and therapy.Nature reviews. Immunology · 2025Review
- Air artifact suppression in phase contrast micro-CT using conditional generative adversarial networks.Journal of synchrotron radiation · 2025Article
- Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparingmSystems · 2025Article
- Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung.bioRxiv : the preprint server for biology · 2025Article
- Microenvironments of tuberculous granuloma: advances and opportunities for therapy.Frontiers in immunology · 2025Review
- Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the Second International Post-Tuberculosis Symposium.American journal of respiratory and critical care medicine · 2024Review
- Agent-based model predicts that layered structure and 3D movement work synergistically to reduce bacterial load in 3D in vitro models of tuberculosis granuloma.PLoS computational biology · 2024Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
12 authors at 6 institutions in 2 countries.
Gordon WellsAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0003-2328-5208
Joel N GlasgowDepartment of Microbiology and.
Kievershen NarganAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Kapongo LumambaAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Rajhmun MadanseinDepartment of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Kameel MaharajDepartment of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Robert L HunterDepartment of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas.
Threnesan NaidooDepartment of Anatomical Pathology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa; and.
Llelani CoetzerComputed Tomography Scanner Facility, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa.
Stephan le RouxComputed Tomography Scanner Facility, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa.
Anton du PlessisComputed Tomography Scanner Facility, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa.
Adrie J C SteynAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0001-9177-8827
Africa Health Research Institute · ZAStellenbosch University · ZAUniversity of KwaZulu-Natal · ZAAfrica Center · USNational Health Laboratory Service · ZAThe University of Texas Health Science Center at Houston · US
Funding
Hydrogen Sulfide and Tuberculosis DiseaseR01AI134810 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2018 to 2021
$2.2MInterplay between the Mtb electron transport chain and carbon metabolismR01AI137043 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2019 to 2023
$2.1MHeme oxygenase-1 and the bioenergetic threshold of latent TB and HIV co-infectionR01AI111940 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2015 to 2019
$2.0MMETABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR33AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2020 to 2023
$2.0MMETABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR61AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2018 to 2019
$1.0MImmunometabolism of M. tuberculosis/HIV co-infectionR21AI127182 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2016 to 2017
$349kNIAID NIH HHS R01 AI111940NIAID NIH HHS R01 AI134810NIAID NIH HHS R01 AI137043NIAID NIH HHS R21 AI127182NIAID NIH HHS R33 AI138280NIAID NIH HHS R61 AI138280
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overFemaleGranulomaHumansImaging, Three-DimensionalLungMaleMiddle AgedMycobacterium tuberculosisSouth AfricaTuberculosis, PulmonaryX-Ray Microtomographybronchogenic spreadcomputed tomographyimagingMycobacterium tuberculosistree-in-bud
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.