Evidence map›Paper›PMID 34015020›Full record

ArticlePloS one2021

A machine learning prediction model for waiting time to kidney transplant.

Juliana Feiman Sapiertein Silva, Gustavo Fernandes Ferreira, Marcelo Perosa, Hong Si Nga, Luis Gustavo Modelli de Andrade

Abstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juliana Feiman Sapiertein SilvaDepartment of Internal Medicine-UNESP, Univ Estadual Paulista, Botucatu, Brazil.
Gustavo Fernandes FerreiraTransplant Unit-Santa Casa Juiz de Fora, Juiz de Fora, Brazil.
Marcelo PerosaKidney-Pancreas Transplantation Service of Leforte and Oswaldo Cruz Hospitals, São Paulo, Brazil.
Hong Si NgaDepartment of Internal Medicine-UNESP, Univ Estadual Paulista, Botucatu, Brazil.
Luis Gustavo Modelli de AndradeDepartment of Internal Medicine-UNESP, Univ Estadual Paulista, Botucatu, Brazil.ORCID 0000-0002-0230-0766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPredicting waiting time for a deceased donor kidney transplant can help patients and clinicians to discuss management and contribute to a more efficient use of resources. This study aimed at developing a predictor model to estimate time on a kidney transplant waiting list using a machine learning approach.

methodsA retrospective cohort study including data of patients registered, between January 1, 2000 and December 31, 2017, in the waiting list of São Paulo State Organ Allocation System (SP-OAS) /Brazil. Data were randomly divided into two groups: 75% for training and 25% for testing. A Cox regression model was fitted with deceased donor transplant as the outcome. Sensitivity analyses were performed using different Cox models. Cox hazard ratios were used to develop the risk-prediction equations.

resultsOf 54,055 records retrieved, 48,153 registries were included in the final analysis. During the study period, approximately 1/3 of the patients were transplanted with a deceased donor. The major characteristics associated with changes in the likelihood of transplantation were age, subregion, cPRA, and frequency of HLA-DR, -B and -A. The model developed was able to predict waiting time with good agreement in internal validation (c-index = 0.70).

conclusionThe kidney transplant waiting time calculator developed shows good predictive performance and provides information that may be valuable in assisting candidates and their providers. Moreover, it can significantly improve the use of economic resources and the management of patient care before transplant.

Indexed as

AdolescentAdultBrazilHumansKidney Failure, ChronicKidney TransplantationMachine LearningMaleMiddle AgedRegistriesTissue and Organ ProcurementTissue DonorsWaiting ListsYoung Adult

Identifiers

PMID34015020
PMCPMC8136711

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.