Evidence map›Paper›PMID 34014802›Full record

ArticleCell adhesion & migration2021

Role of laminin and cognate receptors in cholangiocarcinoma cell migration.

Kittiya Islam, Parichut Thummarati, Pakkanun Kaewkong, Banchob Sripa, Tuangporn Suthiphongchai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kittiya IslamDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-9266-4434
Parichut ThummaratiDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.ORCID 0000-0002-0308-0769
Pakkanun KaewkongDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Banchob SripaDepartment of Pathology, Faculty of Medicine, Khon Kaen University, and the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, Thailand.ORCID 0000-0001-8899-5919
Tuangporn SuthiphongchaiDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.ORCID 0000-0002-0124-7780
Mahidol University · THKhon Kaen University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell-matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA.

Indexed as

Biomarkers, TumorCell Line, TumorCell MovementCholangiocarcinomaFemaleHumansIntegrin beta4LamininLymphatic MetastasisMaleMiddle AgedNeoplasm MetastasisReceptors, LamininBiomarkers, TumorIntegrin beta4ITGB4 protein, humanLamininReceptors, Laminin37/67-kDa human laminin receptorcell migrationcholangiocarcinomaextracellular matrixintegrin β4laminin

Identifiers

PMID34014802
PMCPMC8143218
OpenAlexW3163414149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.