Evidence map›Paper›PMID 34014658›Full record

ArticleACS sensors2021

Thermosensitive and Conductive Hybrid Polymer for Real-Time Monitoring of Spheroid Growth and Drug Responses.

Zuan-Tao Lin, Jianhua Gu, Huie Wang, Albon Wu, Jingying Sun, Shuo Chen, Yaxi Li, Yifei Kong, Mei X Wu, Tianfu Wu

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zuan-Tao LinDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, United States.ORCID 0000-0001-5054-3773
Jianhua GuElectron Microscopy Core, Houston Methodist Research Institute, Houston, Texas 77030, United States.
Huie WangElectron Microscopy Core, Houston Methodist Research Institute, Houston, Texas 77030, United States.
Albon WuDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, United States.
Jingying SunDepartment of Physics and TcSUH, University of Houston, Houston, Texas 77204, United States.
Shuo ChenDepartment of Physics and TcSUH, University of Houston, Houston, Texas 77204, United States.
Yaxi LiDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, United States.
Yifei KongWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, United States.
Mei X WuWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, United States.
Tianfu WuDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, United States.ORCID 0000-0003-4406-1449
University of Houston · USHarvard University · USHouston Methodist · US

Funding

A biomarker panel based smart mini-array system for the homecare of autoimmune kidney diseasesR01AG062987 · NIA · UNIVERSITY OF HOUSTON · PI WU, TIANFU · 2019 to 2023
$2.2M
NIA NIH HHS R01 AG062987
6 · The paper itself

Abstract

Three-dimensional (3D) cell culture based on polymer scaffold provides a promising tool to mimic a physiological microenvironment for drug testing; however, the next-generation cell activity monitoring technology for 3D cell culture is still challenging. Conventionally, drug efficacy evaluation and cell growth heavily rely on cell staining assays, using optical devices or flow cytometry. Here, we report a dual-function polymer scaffold (DFPS) composed of thermosensitive, silver flake- and gold nanoparticle-decorated polymers, enabling conductance change upon cell proliferation or death for

Indexed as

Metal NanoparticlesPharmaceutical PreparationsGoldPolymersSpheroids, CellularGoldPharmaceutical PreparationsPolymers3D cell culturebreast cancercell sensordrug screeningthermosensitive polymer

Identifiers

PMID34014658
PMCPMC8541264
OpenAlexW3163179947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.