Evidence map›Paper›PMID 34014654›Full record

ArticleJournal of the American Chemical Society2021

Remarkable and Unexpected Mechanism for (

Wei Zhu, Peter F Doubleday, Arseniy Butrin, Pathum M Weerawarna, Rafael D Melani, Daniel S Catlin, Timothy A Dwight, Dali Liu, Neil L Kelleher, Richard B Silverman

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Inactivation of ornithine aminotransferase by (1Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  4. Article
  5. Synthesis of (2The Journal of organic chemistry · 2024
    Article
  6. Article
  7. Information-Rich, Dual-FunctionJournal of the American Chemical Society · 2023
    Article
  8. Article
  9. Rational Design, Synthesis, and Mechanism of (3Journal of the American Chemical Society · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wei ZhuDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
Peter F DoubledayDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
Arseniy ButrinDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Pathum M WeerawarnaDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
Rafael D MelaniDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
Daniel S CatlinDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Timothy A DwightDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0002-7587-703X
Neil L KelleherDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8815-3372
Richard B SilvermanDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-9034-1084
Northwestern University · USLoyola University Chicago · US

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
NCI NIH HHS R01 CA260250NIDA NIH HHS P30 DA018310NIDA NIH HHS R01 DA030604NIH HHS S10 OD025194
6 · The paper itself

Abstract

Human ornithine aminotransferase (

Indexed as

Enzyme InhibitorsHumansKineticsMass SpectrometryModels, MolecularMolecular StructureOrnithine-Oxo-Acid TransaminaseEnzyme InhibitorsOAT protein, humanOrnithine-Oxo-Acid Transaminase

Identifiers

PMID34014654
PMCPMC8369387
OpenAlexW3161790388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.