Evidence map›Paper›PMID 34014614›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.

Christine M Lin, Ronald G Gill, Borna Mehrad

Open access · greenAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. The Transplant Bellwether: Endothelial Cells in Antibody-Mediated Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christine M LinDepartment of Medicine, University of Florida, Gainesville, Florida.ORCID 0000-0001-5893-797X
Ronald G GillDepartment of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-7520-4401
Borna MehradDepartment of Medicine, University of Florida, Gainesville, Florida.ORCID 0000-0001-5198-065X
University of Florida · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Multiscale modeling of the role of heme during invasive pulmonary aspergillosisR01AI135128 · NIAID · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2018 to 2026
$4.9M
Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens.U01EB024501 · NIBIB · UNIVERSITY OF FLORIDA · PI LAUBENBACHER, REINHARD, MEHRAD, BORNA · 2017 to 2020
$2.9M
Divergent Pathways of Indirect CD4+ T Cell Dependent Chronic Allograft DysfunctionK08HL136847 · NHLBI · UNIVERSITY OF FLORIDA · PI LIN, CHRISTINE MAYLYN · 2017 to 2021
$784k
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS K08 HL136847NHLBI NIH HHS L30 HL129243NIAID NIH HHS L30 AI107942NIAID NIH HHS R01 AI135128NIBIB NIH HHS U01 EB024501NIH HHS 1K08HL136847-01
6 · The paper itself

Abstract

Chronic rejection is among the most pressing clinical challenges in solid organ transplantation. Interestingly, in a mouse model of heterotopic heart transplantation, antibody-dependent, natural killer (NK) cell-mediated chronic cardiac allograft vasculopathy occurs in some donor-recipient strain combinations, but not others. In this study, we sought to identify the mechanism underlying this unexplained phenomenon. Cardiac allografts from major histocompatibility complex (MHC) mismatched donors were transplanted into immune-deficient C57Bl/6.rag

Indexed as

Heart TransplantationNK Cell Lectin-Like Receptor Subfamily KAnimalsAntibodies, MonoclonalEndothelial CellsGraft RejectionMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLReceptors, Natural Killer CellAntibodies, MonoclonalNK Cell Lectin-Like Receptor Subfamily KReceptors, Natural Killer Cellanimal models: murinebasic (laboratory) research / scienceheart (allograft) function / dysfunctionheart transplantation / cardiologyimmunobiologynatural killer (NK) cells / NK receptorsrejection: antibody-mediated (ABMR)rejection: chronic

Identifiers

PMID34014614
PMCPMC9036609
OpenAlexW3161156336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.