Evidence map›Paper›PMID 34014536›Full record

ArticleAdvances in experimental medicine and biology2021

The Heterogeneity of Breast Cancer Metabolism.

Jessica Tan, Anne Le

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  7. Acetone extracts of BerberisTurkish journal of medical sciences · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Diabetes and Cancer: The Epidemiological and Metabolic Associations.Advances in experimental medicine and biology · 2021
    Article
  14. Article
  15. Glutamine Metabolism in Cancer.Advances in experimental medicine and biology · 2021
    Article
  16. The Intratumoral Heterogeneity of Cancer Metabolism.Advances in experimental medicine and biology · 2021
    Article
  17. Glucose Metabolism in Cancer: The Warburg Effect and Beyond.Advances in experimental medicine and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jessica TanWayne State University School of Medicine, Detroit, MI, USA.
Anne LeDepartment of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. annele@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in screening, therapy, and surveillance that have improved patient survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women [1]. Breast cancer is a highly heterogeneous disease rooted in a genetic basis, influenced by extrinsic stimuli, and reflected in clinical behavior. The diversity of breast cancer hormone receptor status and the expression of surface molecules have guided therapy decisions for decades; however, subtype-specific treatment often yields diverse responses due to varying tumor evolution and malignant potential. Although the mechanisms behind breast cancer heterogeneity is not well understood, available evidence suggests that studying breast cancer metabolism has the potential to provide valuable insights into the causes of these variations as well as viable targets for intervention.

Indexed as

Breast NeoplasmsFemaleHormonesHumansHormonesBreast cancerCholine metabolismEstrogen metabolismEstrogen receptor statusGlycolytic upregulationIntratumoral heterogeneityMetabolic adaptivityMetabolic fingerprintSerine biosynthesis

Identifiers

PMID34014536
PMCPMC9703239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.