Evidence map›Paper›PMID 34014424›Full record

ReviewClinical & experimental metastasis2021

Myeloid derived suppressor cells and the release of micro-metastases from dormancy.

Saraswoti Khadge, Kathryn Cole, James E Talmadge

Open access · greenAbstract readReview
In one paragraph

Review in Clinical & experimental metastasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Saraswoti KhadgeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0002-6621-0102
Kathryn ColeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0002-0452-9636
James E TalmadgeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. jtalmadg@unmc.edu.ORCID 0000-0002-6328-6056
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Tissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1M
NCI NIH HHS P30 CA036727NCI NIH HHS P50 CA127297
6 · The paper itself

Abstract

Metastasis is the primary cause of cancer mortality and an improved understanding of its pathology is critical to the development of novel therapeutic approaches. Mechanism-based therapeutic strategies require insight into the timing of tumor cell dissemination, seeding of distant organs, formation of occult lesions and critically, their release from dormancy. Due to imaging limitations, primary tumors can only be detected when they reach a relatively large size (e.g. > 1 cm

Indexed as

AnimalsHumansMyeloid-Derived Suppressor CellsNeoplasm MicrometastasisNeoplasmsTumor EscapeCirculating tumor cellsDormancyMetastasisMyeloid derived suppressor cellsPre-metastatic niche

Identifiers

PMID34014424
PMCPMC8319840
OpenAlexW3163457169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.