Evidence map›Paper›PMID 34014254›Full record

ArticleThe Journal of experimental medicine2021

CD1a autoreactivity: When size does matter.

Laurent Gapin

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Laurent GapinDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-9730-5174
National Jewish Health · US

Funding

TCR signal strength and iNKT cell subset developmentR01AI130198 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2018 to 2022
$1.9M
Transcriptional Regulation of Innate T cell fateR21AI163454 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2021 to 2022
$428k
Role of mCD1D2 in iNKT cell development and functionsR21AI135339 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2018 to 2019
$415k
NIAID NIH HHS R01 AI130198NIAID NIH HHS R21 AI135339NIAID NIH HHS R21 AI163454
6 · The paper itself

Abstract

CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but instead capture certain lipid classes that broadly interfere with the binding of autoreactive T cell antigen receptors to the target CD1a. These findings provide new potential therapeutic avenues for manipulating CD1a autoreactive T cell responses.

Indexed as

Antigens, CD1Receptors, Antigen, T-CellHumansLipidsSkinT-LymphocytesAntigens, CD1LipidsReceptors, Antigen, T-Cell

Identifiers

PMID34014254
PMCPMC8142285
OpenAlexW3163834608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.