ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Highly Active Halogen Bonding and Chalcogen Bonding Chloride Transporters with Non-Protonophoric Activity.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- Steric Control of Cooperative Anion Transport Mediated by β- and δ‑Hexachlorocyclohexane Multivalent Carriers.JACS Au · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Chloride Selective, Nonprotonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Taxonomy of Chemical Bondings: Opportunities and Challenges.Angewandte Chemie (International ed. in English) · 2025Article
- 6-Aminocoumarin-derived Schiff base gelators: aggregation and sensing of CNRSC advances · 2024Article
- Exploring the Effects of Se Basicity on a Te···Se Interaction Supported by a Rigid Indazolium Backbone.Organometallics · 2024Article
- Tunable Pnictogen Bonding at the Service of Hydroxide Transport across Phospholipid Bilayers.Journal of the American Chemical Society · 2024Article
- Coupling Photoresponsive Transmembrane Ion Transport with Transition Metal Catalysis.Journal of the American Chemical Society · 2024Article
- Selective recognition and extraction of iodide from pure water by a tripodal selenoimidazol(ium)-based chalcogen bonding receptor.iScience · 2024Article
- Fullerene-Functionalized Halogen-Bonding Heteroditopic Hosts for Ion-Pair Recognition.Journal of the American Chemical Society · 2023Article
- FluorogenicJACS Au · 2023Article
- Halogen bonding relay and mobile anion transporters with kinetically controlled chloride selectivity.Chemical science · 2023Article
- Engineered Binding Microenvironments in Halogen Bonding Polymers for Enhanced Anion Sensing.Angewandte Chemie (International ed. in English) · 2023Article
- Allosteric and Electrostatic Cooperativity in a Heteroditopic Halogen Bonding Receptor System.Chemistry, an Asian journal · 2023Article
- Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores.Journal of the American Chemical Society · 2023Article
- Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol-Mediated Uptake with Tetrel-Centered Exchange Cascades, Assisted by Halogen-Bonding Switches.Angewandte Chemie (International ed. in English) · 2022Article
- Anti-Hofmeister Anion Selectivity via a Mechanical Bond Effect in Neutral Halogen-Bonding [2]Rotaxanes.Angewandte Chemie (International ed. in English) · 2022Article
- Anion Recognition with Antimony(III) and Bismuth(III) Triaryl-Based Pnictogen Bonding Receptors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Fast relaxing red and near-IR switchable azobenzenes with chalcogen and halogen substituents: periodic trends, tuneable thermal half-lives and chalcogen bonding.Chemical science · 2022Article
- Controlling transmembrane ion transportChemical science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Synthetic anion transporters show much promise as potential anti-cancer agents and therapeutics for diseases associated with mis-regulation of protein anion channels. In such applications high activity and anion selectivity are crucial to overcome competing proton or hydroxide transport which dissipates cellular pH gradients. Here, highly active bidentate halogen bonding and chalcogen bonding anion carriers based on electron deficient iodo- and telluromethyl-triazole derivatives are reported. Anion transport experiments in lipid bilayer vesicles reveal record nanomolar chloride transport activity for the bidentate halogen bonding anion carrier, and remarkably high chloride over proton/hydroxide selectivity for the chalcogen bonding anionophore. Computational studies provide further insight into the role of sigma-hole mediated anion recognition and desolvation at the membrane interface. Comparison with hydrogen bonding analogues demonstrates the importance of employing sigma-hole donor motifs in synthetic anionophores for achieving both high transport activity and selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.