ArticleeLife2021
Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations.
Open access · goldAbstract readVideo-Audio Media
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives.Journal of neurochemistry · 2026Review
- Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rapid and robust generation of cardiomyocyte-specific crispants in zebrafish using the cardiodeleter system.Cell reports methods · 2025Article
- Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish.eLife · 2025Article
- CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice.JCI insight · 2024Article
- Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Review
- Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.bioRxiv : the preprint server for biology · 2024Article
- Phenomena of Intussusceptive Angiogenesis and Intussusceptive Lymphangiogenesis in Blood and Lymphatic Vessel Tumors.Biomedicines · 2024Article
- Transluminal Pillars-Their Origin and Role in the Remodelling of the Zebrafish Caudal Vein Plexus.International journal of molecular sciences · 2023Article
- Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research.Military Medical Research · 2023Review
- Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.International journal of molecular sciences · 2022Review
- Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.The Journal of clinical investigation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Wenqing LiDepartment of Medicine, University of California, San Diego, La Jolla, United States.
Virginia TranDepartment of Medicine, University of California, San Diego, La Jolla, United States.
Iftach ShakedDepartment of Physics, University of California, San Diego, La Jolla, United States.
Belinda XueDepartment of Medicine, University of California, San Diego, La Jolla, United States.
Thomas MooreNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, United States.
Rhonda LightleNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, United States.
David KleinfeldDepartment of Physics, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-9797-4722
Issam A AwadNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, United States.
Mark H GinsbergDepartment of Medicine, University of California, San Diego, La Jolla, United States.ORCID 0000-0002-5685-5417
University of California San Diego · USUniversity of Chicago · US
Funding
The Hemostasis, Thrombosis, and Inflammation Models CoreP01HL151433 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark HOWARD Ginsberg · 2020 to 2026
$16.4MSomatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI KAHN, MARK L · 2015 to 2024
$12.9MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MResilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8MDeconvoluting the Vascular AdhesomeR35HL139947 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2018 to 2024
$5.5MThe impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2MNHLBI NIH HHS P01 HL151433NHLBI NIH HHS R35 HL139947NINDS NIH HHS P01 NS092521NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS108472NINDS NIH HHS R35 NS097265
Abstract
Mosaic inactivation of
Indexed as
AnimalsAnimals, Genetically ModifiedBrainCerebrovascular CirculationDisease Models, AnimalGene Expression Regulation, DevelopmentalGene SilencingGenetic Predisposition to DiseaseHemangioma, Cavernous, Central Nervous SystemKruppel-Like Transcription FactorsMosaicismMuscle ProteinsNeovascularization, PathologicPhenotypeSignal TransductionZebrafishccm2 protein, zebrafishKlf2a protein, zebrafishKruppel-Like Transcription FactorsMuscle ProteinsZebrafish Proteinsangiogenesisblood flow signalingcerebral cavernous malformationsdevelopmental biologyzebrafish
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.