Evidence map›Paper›PMID 34013884›Full record

ArticleeLife2021

Somatostatin-expressing parafacial neurons are CO

Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, Daniel K Mulkey

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Kir4.1 channels contribute to astrocyte COCommunications biology · 2024
    Article
  12. Article
  13. Molecular therapy. Methods & clinical development · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Central respiratory chemoreception.Handbook of clinical neurology · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Colin M ClearyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0003-0305-1324
Brenda M MillaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Fu-Shan KuoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Shaun JamesDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
William F FlynnThe Jackson Laboratory for Genomic Medicine, Farmington, United States.ORCID 0000-0001-6533-0340
Paul RobsonThe Jackson Laboratory for Genomic Medicine, Farmington, United States.ORCID 0000-0002-0191-3958
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0002-7040-3927
University of Connecticut · USJackson Laboratory · US

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
Defining Astrocyte Heterogenity Across the Brainstem Respiratory CircuitR21NS099887 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K · 2019 to 2020
$443k
Roles of glycinergic neurons in Dravet syndrome-associated disordered breathing and mortalityF31NS120467 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI MILLA, BRENDA · 2020 to 2024
$166k
Role of P2Y2 in the Regulation of Vascular Tone and Control of BreathingF31HL142227 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI CLEARY, COLIN · 2018 to 2020
$119k
NHLBI NIH HHS F31 HL142227NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL137094NINDS NIH HHS F31 NS120467NINDS NIH HHS R21 NS099887
6 · The paper itself

Abstract

Glutamatergic neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating breathing in response to tissue CO

Indexed as

RespirationAnimalsCarbon DioxideChemoreceptor CellsDisease Models, AnimalEpilepsies, MyoclonicFemaleGlutamic AcidHydrogenIntralaminar Thalamic NucleiLungMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicCarbon DioxideGlutamic AcidHydrogenNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseSomatostatinchemoreceptiondisinhibitionmouseneuroscienceretrotrapezoid nucleus

Identifiers

PMID34013884
PMCPMC8169115
OpenAlexW3160891991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.