Evidence map›Paper›PMID 34013872›Full record

ArticleEmerging infectious diseases2021

Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020

Kirsten E Wiens, Pinyi Nyimol Mawien, John Rumunu, Damien Slater, Forrest K Jones, Serina Moheed, Andrea Caflisch, Bior K Bior, Iboyi Amanya Jacob, Richard Lino Lako and 16 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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  13. Review
  14. Seroincidence of Enteric Fever, Juba, South Sudan.Emerging infectious diseases · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Kirsten E Wiens
Pinyi Nyimol Mawien
John Rumunu
Damien Slater
Forrest K Jones
Serina Moheed
Andrea Caflisch
Bior K Bior
Iboyi Amanya Jacob
Richard Lino Lako
Argata Guracha Guyo
Olushayo Oluseun Olu
Sylvester Maleghemi
Andrew Baguma
Juma John Hassen
Sheila K Baya
Lul Deng
Justin Lessler
Maya N Demby
Vanessa Sanchez
Rachel Mills
Clare Fraser
Richelle C Charles
Jason B Harris
Andrew S Azman
Joseph F Wamala

Funding

Estimating Cholera Burden with Cross-sectional Immunologic DataR01AI135115 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2018 to 2022
$3.4M
ACL HHS U01CK000490NIAID NIH HHS R01 AI135115
6 · The paper itself

Abstract

Relatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10-September 11, 2020, we recruited 2,214 participants for a representative household-based cross-sectional serosurvey in Juba, South Sudan. We found 22.3% of participants had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain IgG titers above prepandemic levels. After accounting for waning antibody levels, age, and sex, we estimated that 38.3% (95% credible interval 31.8%-46.5%) of the population had been infected with SARS-CoV-2. At this rate, for each PCR-confirmed SARS-CoV-2 infection reported by the Ministry of Health, 103 (95% credible interval 86-126) infections would have been unreported, meaning SARS-CoV-2 has likely spread extensively within Juba. We also found differences in background reactivity in Juba compared with Boston, Massachusetts, USA, where the immunoassay was validated. Our findings underscore the need to validate serologic tests in sub-Saharan Africa populations.

Indexed as

COVID-19SARS-CoV-2Africa South of the SaharaAntibodies, ViralBostonCross-Sectional StudiesHumansImmunoglobulin GMassachusettsSeroepidemiologic StudiesSouth SudanAntibodies, ViralImmunoglobulin Gantibodiescoronavirus diseaseCOVID-19influenzaJubarespiratory infectionsSARS-CoV-2seroprevalenceserosurveysevere acute respiratory syndrome coronavirus 2South Sudansub-Saharan Africaviruses

Identifiers

PMID34013872
PMCPMC8153877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.