Evidence map›Paper›PMID 34013753›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.

Christopher Lopez, Tanja Taivassalo, Maria G Berru, Andres Saavedra, Hannah C Rasmussen, Abhinandan Batra, Harneet Arora, Alex M Roetzheim, Glenn A Walter, Krista Vandenborne and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06290713 (Vasodilators and Exercise as Adjuvant Therapy for Duchenne Muscular Dystrophy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06290713 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Vasodilators and Exercise as Adjuvant Therapy for Duchenne Muscular Dystrophy (VASO-REx Study)

TypeinterventionalSponsorUniversity of FloridaRan2024 to 2026Enrolled50ConditionsDuchenne Muscular Dystrophy, Duchenne Disease, Muscular Dystrophy, Muscular Dystrophy in ChildrenArmsTadalafil, Placebo, Exercise Training
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christopher LopezDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Tanja TaivassaloDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Maria G BerruDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Andres SaavedraDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Hannah C RasmussenDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Abhinandan BatraDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Harneet AroraDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Alex M RoetzheimDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Glenn A WalterDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Krista VandenborneDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
Sean C ForbesDepartment of Physical Therapy, University of Florida, Gainesville, Florida.
University of Florida · US

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
MR Assessment of Bioenergetics and Microvascular Function in Dystrophic MuscleR01AR070101 · NIAMS · UNIVERSITY OF FLORIDA · PI FORBES, SEAN C · 2016 to 2020
$1.7M
NIAMS NIH HHS R01 AR070101NIAMS NIH HHS U54 AR052646
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is characterized by a progressive replacement of muscle by fat and fibrous tissue, muscle weakness, and loss of functional abilities. Impaired vasodilatory and blood flow responses to muscle activation have also been observed in DMD and associated with mislocalization of neuronal nitric oxide synthase mu (nNOSμ) from the sarcolemma. The objective of this study was to determine whether the postcontractile blood oxygen level-dependent (BOLD) MRI response is impaired in DMD and correlated with established markers of disease severity in DMD, including MRI muscle fat fraction (FF) and clinical functional measures. Young boys with DMD (

Indexed as

Muscular Dystrophy, DuchenneHumansLegMagnetic Resonance ImagingMaleMuscle ContractionMuscle, Skeletalblood oxygenation level dependentDuchenne muscular dystrophymagnetic resonance imagingmicrovascularskeletal muscle

Identifiers

PMID34013753
PMCPMC8325615
OpenAlexW3162017533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.