Evidence map›Paper›PMID 34013750›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Muscle-specific deletion of the vitamin D receptor in mice is associated with diaphragm muscle weakness.

Matthew J Fogarty, Louis L Losbanos, Theodore A Craig, Carmen J Reynolds, Alyssa D Brown, Rajiv Kumar, Gary C Sieck

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. [Application of Animal Models in Research on Hypoxia-Related Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  2. Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  3. Article
  4. Article
  5. Sarcopenia of the longitudinal tongue muscles in rats.Respiratory physiology & neurobiology · 2024
    Article
  6. Article
  7. Mitochondrial adaptations to inactivity in diaphragm muscle fibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  8. Diaphragm muscle function in a mouse model of early-onset spasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew J FogartyDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Louis L LosbanosDivision of Nephrology & Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Theodore A CraigDivision of Nephrology & Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Carmen J ReynoldsDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Alyssa D BrownDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4422-3356
Rajiv KumarDivision of Nephrology & Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Gary C SieckDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · US

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
KIDNEY DISEASES RESEARCH TRAINING PROGRAMT32DK007013 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 1986 to 2023
$3.7M
Fractures and bone disease in living kidney donorsR01DK125252 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2020 to 2022
$2.1M
Mechanisms of age-related susceptibility of NMJ functionR01AG057052 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2017 to 2021
$2.0M
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR01DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2017 to 2019
$716k
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR56DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2020 to 2020
$103k
NHLBI NIH HHS R01 HL146114NIA NIH HHS R01 AG044615NIA NIH HHS R01 AG057052NIDDK NIH HHS R01 DK107870NIDDK NIH HHS R01 DK125252NIDDK NIH HHS R56 DK107870NIDDK NIH HHS T32 DK007013
6 · The paper itself

Abstract

Diseases or conditions where diaphragm muscle (DIAm) function is impaired, including chronic obstructive pulmonary disease, cachexia, asthma, and aging, are associated with an increased risk of pulmonary symptoms, longer duration of hospitalizations, and increasing requirements for mechanical ventilation. Vitamin D deficiency is associated with proximal muscle weakness that resolves following therapy with vitamin D

Indexed as

DiaphragmReceptors, CalcitriolAnimalsMiceMice, KnockoutMuscle Fibers, SkeletalMuscle, SkeletalMuscle WeaknessVitamin DReceptors, CalcitriolVdr protein, mouseVitamin Dfatiguemuscle fiber typemuscle-specific forcevitamin Dvitamin D receptor

Identifiers

PMID34013750
PMCPMC8325609
OpenAlexW3160950824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.