Evidence map›Paper›PMID 34013738›Full record

ArticleJournal of the American Heart Association2021

Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.

Wei Wang, Ran Li, Wanying Miao, Cody Evans, Liping Lu, Jingjun Lyu, Xuan Li, David S Warner, Xiaoping Zhong, Ulrike Hoffmann and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Isolating Immune Cells from Mouse Brain and Skull.Journal of visualized experiments : JoVE · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Wei WangDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Ran LiDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Wanying MiaoDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Cody EvansDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Liping LuDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Jingjun LyuDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Xuan LiDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
David S WarnerDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Xiaoping ZhongDepartment of Pediatrics Duke University Medical Center Durham NC.
Ulrike HoffmannDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Huaxin ShengDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Wei YangDepartment of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.
Duke Medical Center · USDuke University · US

Funding

Mast cell activation as a determinant of neurologic injury after cardiac arrestR21NS117973 · NINDS · DUKE UNIVERSITY · PI YANG, WEI · 2020 to 2021
$453k
NINDS NIH HHS R21 NS117973
6 · The paper itself

Abstract

Background Animal disease models represent the cornerstone in basic cardiac arrest (CA) research. However, current experimental models of CA and resuscitation in mice are limited. In this study, we aimed to develop a mouse model of asphyxial CA followed by cardiopulmonary resuscitation (CPR), and to characterize the immune response after asphyxial CA/CPR. Methods and Results CA was induced in mice by switching from an O

Indexed as

Immunity, CellularAnimalsAsphyxiaDisease Models, AnimalHeart ArrestLymphocytesLymphopoiesisMaleMiceMice, Inbred C57BLResuscitationSeverity of Illness Indexasphyxiacardiac arrestimmunologyimmunosuppressionlymphocytelymphopenia

Identifiers

PMID34013738
PMCPMC8483518
OpenAlexW3163270732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.