SynthesisJournal of the American Heart Association2021
Does the Age of Sudden Cardiac Death in Family Members Matter in Brugada Syndrome?
Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Performance of Multiparametric Models in Patients With Brugada Syndrome: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Does the Age of Sudden Cardiac Death in Family Members Matter in Brugada Syndrome?Journal of the American Heart Association · 2021Pooled it
- Risk stratification of major arrhythmia events in Japanese patients with Brugada syndrome using machine learning models.Heart rhythm O2 · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Spontaneous type 1 ECG and arrhythmic risk in Brugada syndrome: A meta-analysis of adjusted time-to-event data.Heart rhythm O2 · 2025Article
- Brugada syndrome risk scores: what we've learned and what's next.Frontiers in cardiovascular medicine · 2025Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Risk factors of sudden cardiac death in Egyptian patients younger than 40 years.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Article
- Unmasking a Silent Killer and Understanding Sudden Cardiac Death in Brugada Syndrome: A Traditional Review.Cureus · 2023Review
- Management of Inherited Arrhythmia Syndromes: A HiRO Consensus Handbook on Process of Care.CJC open · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- When Brugada syndrome is at risk of sudden death: clinical and anatomical aspects.European heart journal supplements : journal of the European Society of Cardiology · 2022Article
- Brugada Syndrome as a Major Cause of Sudden Cardiac Death in Asians.JACC. Asia · 2022Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Brugada syndrome is an inherited cardiac channelopathy associated with major arrhythmic events (MAEs). The presence of a positive family history of sudden cardiac death (SCD) as a risk predictor of MAE remains controversial. We aimed to examine the association between family history of SCD and MAEs stratified by age of SCD with a systematic review and meta-analysis. Methods and Results We searched the databases of MEDLINE and EMBASE from January 1992 to January 2020. Data from each study were combined using the random-effects model. Fitted metaregression was performed to evaluate the association between the age of SCD in families and the risk of MAE. Twenty-two studies from 2004 to 2019 were included in this meta-analysis involving 3386 patients with Brugada syndrome. The overall family history of SCD was not associated with increased risk of MAE in Brugada syndrome (pooled odds ratio [OR], 1.11; 95% CI, 0.82-1.51;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.