Evidence map›Paper›PMID 34013643›Full record

ReviewClinical & experimental ophthalmology2021

Stargardt disease: Multimodal imaging: A review.

Rachael C Heath Jeffery, Fred K Chen

Abstract readReview
In one paragraph

Review in Clinical & experimental ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Stargardt macular dystrophy and therapeutic approaches.The British journal of ophthalmology · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Evaluation of Local Rod and Cone Function in Stargardt Disease.Investigative ophthalmology & visual science · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachael C Heath JefferyCentre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute), The University of Western Australia, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0002-9078-7059
Fred K ChenCentre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute), The University of Western Australia, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0003-2809-9930

Funding

Macular Disease Foundation AustraliaMcCusker Charitable FoundationMiocevich Retina FellowshipNational Health & Medical Research Council of Australia GNT1054712National Health & Medical Research Council of Australia GNT116360National Health & Medical Research Council of Australia GNT1188694National Health & Medical Research Council of Australia MRF1142962Telethon-Perth Children's Hospital research fund
6 · The paper itself

Abstract

Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy, characterised by bilateral progressive central vision loss and subretinal deposition of lipofuscin-like substances. Recent advances in molecular diagnosis and therapeutic options are complemented by the increasing recognition of new multimodal imaging biomarkers that may predict genotype and disease progression. Unique non-invasive imaging features of STDG1 are useful for gene variant interpretation and may even provide insight into the underlying molecular pathophysiology. In addition, pathognomonic imaging features of STGD1 have been used to train neural networks to improve time efficiency in lesion segmentation and disease progression measurements. This review will discuss the role of key imaging modalities, correlate imaging signs across varied STGD1 presentations and illustrate the use of multimodal imaging as an outcome measure in determining the efficacy of emerging STGD1 specific therapies.

Indexed as

Retinal DystrophiesTomography, Optical CoherenceFluorescein AngiographyHumansLipofuscinStargardt DiseaseLipofuscinfundus autofluorescenceinherited retinal diseasesocular coherence tomographyretinaretinal dystrophy

Identifiers

PMID34013643
PMCPMC8366508

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.