Evidence map›Paper›PMID 34013611›Full record

ArticleThe International journal of eating disorders2021

Brain-gut psychotherapies: Promising tools to address gastrointestinal problems in patients with eating disorders.

Jennifer E Wildes, Alyse Bedell, Andrea K Graham, Meredith Kells

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Altered Gastrointestinal Interoception in Anorexia Nervosa Predicts Relapse.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer E WildesDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0950-4347
Alyse BedellDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Andrea K GrahamCenter for Behavioral Intervention Technologies, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-9736-8906
Meredith KellsDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9982-9964
University of Chicago · USNorthwestern University · US

Funding

Regional Postdoctoral Training Grant in Eating Disorders ResearchT32MH082761 · NIMH · UNIVERSITY OF MINNESOTA · PI CAROL B. PETERSON · 2009 to 2026
$6.2M
SOLVE IT: Real Risk Reduction for MSMR01MH082671 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILLER, LYNN C · 2008 to 2012
$3.4M
Testing Intervention Strategies for Addressing Obesity and Binge EatingK01DK116925 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRAHAM, ANDREA KASS · 2018 to 2022
$799k
NIDDK NIH HHS K01 DK116925NIDDK NIH HHS K01DK116925NIMH NIH HHS R01 MH082671NIMH NIH HHS T32MH082671NIMH NIH HHS T32 MH082761
6 · The paper itself

Abstract

Gastrointestinal (GI) problems are common in individuals with eating disorders (EDs) and associated with distress, impairment, and increased healthcare utilization. GI symptoms may be exacerbated by meals and other interventions central to ED recovery thereby contributing to negative clinical outcomes. Informed by models emphasizing the role of the brain-gut axis in the expression of GI symptoms, this article describes a program of research to adapt "brain-gut psychotherapies" for EDs. First, the role of the brain-gut axis in GI symptoms is described, and evidence-based brain-gut psychotherapies are reviewed, with an emphasis on cognitive behavioral therapy for GI disorders and gut-directed hypnotherapy. Next, future directions for research in EDs to (a) understand the impact of GI symptoms on illness course and outcome; (b) clarify target engagement; (c) evaluate brain-gut psychotherapies; and (d) optimize intervention reach and delivery are described. We present a conceptual model that emphasizes GI-specific anxiety and altered gut physiology as targets of brain-gut psychotherapies in EDs, and discuss several issues that need to be addressed in designing clinical trials to test these interventions. We also describe how engagement with multidisciplinary stakeholders and use of digital tools could speed translation from the laboratory to clinical settings.

Indexed as

Cognitive Behavioral TherapyFeeding and Eating DisordersGastrointestinal DiseasesBrainHumansPsychotherapybrain-gut psychotherapycognitive behavior therapydigital interventiondisorder of gut-brain interactioneating disorderfunctional gastrointestinal disorderGI-specific anxietygut-directed hypnotherapy

Identifiers

PMID34013611
PMCPMC8962673
OpenAlexW3161505491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.