Evidence map›Paper›PMID 34013439›Full record

ArticlePharmacoEconomics2021

The Growing Burden of Major Depressive Disorders (MDD): Implications for Researchers and Policy Makers.

David Proudman, Paul Greenberg, Dave Nellesen

Abstract readEditorial
In one paragraph

Article in PharmacoEconomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Improvements in health-related quality of life with esketamine nasal spray versus quetiapine extended release.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Observational
  17. Review
  18. Predicting adolescent depression: an interpretable machine learning model.BMC medical informatics and decision making · 2026
    Article
  19. The Impact of Neighbours and Neighbourhoods on Major Depressive Disorders in Adults.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David ProudmanAnalysis Group, Menlo Park, CA, USA.
Paul GreenbergAnalysis Group, Boston, MA, USA.
Dave NellesenAnalysis Group, Menlo Park, CA, USA. dave.nellesen@analysisgroup.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Major Depressive DisorderAdministrative PersonnelComorbidityHumans

Identifiers

PMID34013439
PMCPMC8134814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.