Evidence map›Paper›PMID 34013363›Full record

ArticleMolecular medicine reports2021

Phenylethanol glycosides from Herba Cistanche improve the hypoxic tumor microenvironment and enhance the effects of oxaliplatin via the HIF‑1α signaling pathway.

Limei Wen, Junping Hu, Jiawei Zhang, Jianhua Yang

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Effects of acteoside fromFrontiers in pharmacology · 2024
    Article
  8. Exercise performance reduction and preventive measures in highland sports.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  9. Article
  10. Effect of PhenylEthanol Glycosides fromEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Limei Wen *College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Junping Hu *College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Jiawei ZhangCollege of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Jianhua YangCollege of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Xinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer is one of the most common types of malignant tumor, and is characterized by high malignancy, rapid progression, high morbidity and mortality. Oxaliplatin (OXA) has been reported to have marked efficiency against advanced liver cancer with tolerable toxicity. In solid tumors, the hypoxic microenvironment promotes epithelial‑mesenchymal transition (EMT), which can also induce drug resistance of liver cancer to platinum drugs. Herba Cistanche (

Indexed as

ApoptosisCell Line, TumorCell SurvivalCistancheGlycosidesHep G2 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitLiver NeoplasmsOxaliplatinPhenylethyl AlcoholPlant ExtractsSignal TransductionTumor HypoxiaTumor MicroenvironmentUp-RegulationGlycosidesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitOxaliplatinPhenylethyl AlcoholPlant Extractsepithelial‑mesenchymal transitionHIF‑1α signaling pathwayhypoxialiver cancerphenylethanol glycosides from Herba Cistanche

Identifiers

PMID34013363
PMCPMC8160477
OpenAlexW3160587130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.