ArticleCerebral cortex (New York, N.Y. : 1991)2021
Extensive Cortical Connectivity of the Human Hippocampal Memory System: Beyond the "What" and "Where" Dual Stream Model.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Mental Scene and Memory Construction and the Hippocampus.Hippocampus · 2026Article
- Causal evidence from invasive recordings reveals distributed acoustic feature encoding underlying categorical voice perception.NeuroImage · 2026Article
- Phylogeny of Cortical-Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions.Hippocampus · 2026Article
- EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study.Cerebellum (London, England) · 2026Article
- Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in activations to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus.Biology of sex differences · 2026Article
- Connectivity of the Superior Temporal Polysensory Area With the Presubiculum, Parasubiculum, Entorhinal Cortex, and Claustrum-Endopiriform Complex in the Common Marmoset (Callithrix jacchus).The Journal of comparative neurology · 2026Article
- Sensory network dysregulation in type 2 diabetes: Linking olfactory, visual, and cognitive function.Diabetes, obesity & metabolism · 2026Article
- Distinct contributions of hippocampal pathways in learning regularities and exceptions revealed by functional footprints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Sex-specific hippocampal microstructural alterations in 11-12-year-old adolescents with a history of mild traumatic brain injury.Frontiers in behavioral neuroscience · 2026Article
- Reorganisation of Cortico-Hippocampal White Matter Pathways in Healthy Ageing: Evidence for Paradoxical Shifts in Structural Connectivity.bioRxiv : the preprint server for biology · 2025Article
- In Vivo Quantification of White Matter Pathways in the Human Hippocampus.Human brain mapping · 2025Article
- Soccer Heading Exposure-Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players.Neurology · 2025Article
- Microstructural Changes in Aging Hippocampal Pathways: Insights From the HCP-Aging Diffusion MRI Study.Human brain mapping · 2025Article
- Deep Brain Stimulation Therapy for Drug-Resistant Epilepsy: Present and Future Perspectives.Journal of epilepsy research · 2025Review
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Emotion, Motivation, Reasoning, and How Their Brain Systems Are Related.Brain sciences · 2025Review
- Article
- Linking Memory Impairment to Structural Connectivity in Extrahippocampal Temporal Lobe Epilepsy Surgery.Neurology international · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human hippocampus is involved in forming new memories: damage impairs memory. The dual stream model suggests that object "what" representations from ventral stream temporal cortex project to the hippocampus via the perirhinal and then lateral entorhinal cortex, and spatial "where" representations from the dorsal parietal stream via the parahippocampal gyrus and then medial entorhinal cortex. The hippocampus can then associate these inputs to form episodic memories of what happened where. Diffusion tractography was used to reveal the direct connections of hippocampal system areas in humans. This provides evidence that the human hippocampus has extensive direct cortical connections, with connections that bypass the entorhinal cortex to connect with the perirhinal and parahippocampal cortex, with the temporal pole, with the posterior and retrosplenial cingulate cortex, and even with early sensory cortical areas. The connections are less hierarchical and segregated than in the dual stream model. This provides a foundation for a conceptualization for how the hippocampal memory system connects with the cerebral cortex and operates in humans. One implication is that prehippocampal cortical areas such as the parahippocampal TF and TH subregions and perirhinal cortices may implement specialized computations that can benefit from inputs from the dorsal and ventral streams.
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