Evidence map›Paper›PMID 34013284›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Magnetofluidic platform for rapid multiplexed screening of SARS-CoV-2 variants and respiratory pathogens.

Alexander Y Trick, Fan-En Chen, Liben Chen, Pei-Wei Lee, Alexander C Hasnain, Heba H Mostafa, Karen C Carroll, Tza-Huei Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander Y TrickDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Fan-En ChenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Liben ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Pei-Wei LeeDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Alexander C HasnainDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Heba H MostafaDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Karen C CarrollDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tza-Huei WangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · US

Funding

Technology development for point-of-care detection and antimicrobial susceptibility testing of Neisseria gonorrhoeaeR01AI138978 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF · 2018 to 2021
$5.1M
A "Culture" Shift: Integrated Bacterial Screening and Antibacterial Susceptibility Test on Microfluidic Digital Array for Bloodstream InfectionsR01AI137272 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF, YANG, SAMUEL · 2018 to 2022
$3.6M
Streamlined 15-min HIV Viral Load Self-Testing Using Finger-Stick BloodR61AI154628 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HSIEH, YU-HSIANG, MANABE, YUKARI C · 2020 to 2022
$1.4M
NIAID NIH HHS R01 AI137272NIAID NIH HHS R01 AI138978NIAID NIH HHS R61 AI154628
6 · The paper itself

Abstract

The rise of highly transmissible SARS-CoV-2 variants brings new challenges and concerns with vaccine efficacy, diagnostic sensitivity, and public health responses in the fight to end the pandemic. Widespread detection of variant strains will be critical to inform policy decisions to mitigate further spread, and post-pandemic multiplexed screening of respiratory viruses will be necessary to properly manage patients presenting with similar respiratory symptoms. In this work, we have developed a portable, magnetofluidic cartridge platform for automated PCR testing in <30 min. Cartridges were designed for multiplexed detection of SARS-CoV-2 with either distinctive variant mutations or with Influenza A and B. The platform demonstrated a limit of detection down to 2 copies/µL SARS-CoV-2 RNA with successful identification of B.1.1.7 and B.1.351 variants. The multiplexed SARS-CoV-2/Flu assay was validated using archived clinical nasopharyngeal swab eluates (

Identifiers

PMID34013284
PMCPMC8132258
OpenAlexW3163739567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.