ArticleResearch square2021
Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections.
Charles R Esther, Kyle S Kimura, Yu Mikami, Caitlin E Edwards, Suman R Das, Michael H Freeman, Britton A Strickland, Hunter M Brown, Bronson C Wessinger, Veerain C Gupta and 12 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
22 authors at 2 institutions in 1 country.
Charles R EstherUniversity of North Carolina at Chapel Hill.
Kyle S KimuraVanderbilt University Medical Center.
Yu MikamiUniversity of North Carolina at Chapel Hill.
Caitlin E EdwardsUniversity of North Carolina at Chapel Hill.
Suman R DasVanderbilt University Medical Center.
Michael H FreemanVanderbilt University Medical Center.
Britton A StricklandVanderbilt University Medical Center.
Hunter M BrownVanderbilt University Medical Center.
Bronson C WessingerVanderbilt University Medical Center.
Veerain C GuptaVanderbilt University Medical Center.
Kate Von WahldeVanderbilt University Medical Center.
Quanhu ShengVanderbilt University Medical Center.
Li Ching HuangVanderbilt University Medical Center.
Daniel R BaconUniversity of North Carolina at Chapel Hill.
Adam J KimpleUniversity of North Carolina at Chapel Hill.
Agathe S CeppeUniversity of North Carolina at Chapel Hill.
Takafumi KatoUniversity of North Carolina at Chapel Hill.
Raymond J PicklesUniversity of North Carolina at Chapel Hill.
Scott H RandellUniversity of North Carolina at Chapel Hill.
Ralph S BaricUniversity of North Carolina at Chapel Hill.
Justin H TurnerVanderbilt University Medical Center.
Richard C BoucherUniversity of North Carolina at Chapel Hill.
University of North Carolina at Chapel Hill · USVanderbilt University Medical Center · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MVector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MThe Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2021
$23.9MNorth Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0MDeterminants of Coronavirus Fidelity in Replication and PathogenesisR01AI108197 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARIC, RALPH S, DENISON, MARK R · 2013 to 2022
$6.5MUnderstanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast AsiaU01AI151797 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2020 to 2023
$6.0MSynthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH3HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2016 to 2018
$4.6MMultiscale Biochemical/Biophysical Integration of Pulmonary Mucus TransportR01HL136961 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2017 to 2020
$3.2MIntegrated Metagenomic and Metatranscriptomic Characterization of Inflammatory Chronic Rhinosinusitis EndotypesR21AI142321 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN, TURNER, JUSTIN H · 2020 to 2021
$924kNCATS NIH HHS KL2 TR002490NHLBI NIH HHS P01 HL108808NHLBI NIH HHS R01 HL136961NHLBI NIH HHS UH3 HL123645NIAID NIH HHS R01 AI108197NIAID NIH HHS R21 AI142321NIAID NIH HHS U01 AI151797NIDDK NIH HHS P30 DK065988NIEHS NIH HHS P30 ES010126
6 · The paper itselfAbstract
The nose is the portal for SARS-CoV-2 infection, suggesting the nose as a target for topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson's Baby Shampoo (J&J) was tested as a topical virucidal agent in SARS-CoV-2 infected subjects. Twice daily irrigation of J&J in hypertonic saline, hypertonic saline alone, or no intervention were compared (n = 24/group). Despite demonstrated safety and robust efficacy in
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PMID34013253
PMCPMC8132247
OpenAlexW3163515067
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