Evidence map›Paper›PMID 34013244›Full record

ArticleResearch square2021

Systems biological assessment of human immunity to BNT162b2 mRNA vaccination.

Prabhu S Arunachalam, Madeleine K D Scott, Thomas Hagan, Chunfeng Li, Yupeng Feng, Florian Wimmers, Lilit Grigoryan, Meera Trisal, Venkata Viswanadh Edara, Lilin Lai and 24 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors at 1 institution in 1 country.

Prabhu S Arunachalam *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Madeleine K D Scott *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Thomas Hagan *Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Chunfeng Li *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Yupeng Feng *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Florian Wimmers *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Lilit Grigoryan *Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Meera TrisalInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Venkata Viswanadh EdaraYerkes National Primate Research Center, Atlanta, Georgia, USA.
Lilin LaiYerkes National Primate Research Center, Atlanta, Georgia, USA.
Sarah Esther ChangInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Allan FengInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Shaurya DhingraInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Mihir ShahSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Allie Skye LeeSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Sharon ChinthrajahSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Tina SindherSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Vamsee MallajosyulaInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Fei GaoInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Natalia SigalInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Sangeeta KowliInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Sheena GuptaInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Kathryn PellegriniYerkes National Primate Research Center, Atlanta, Georgia, USA.
Gregory TharpYerkes National Primate Research Center, Atlanta, Georgia, USA.
Sofia Maysel-AuslenderInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Steven BosingerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Holden T MaeckerInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Scott D BoydSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Paul J UtzInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Mehul S SutharYerkes National Primate Research Center, Atlanta, Georgia, USA.
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Kari C NadeauSean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
Bali PulendranInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Stanford University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0M
Computational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4M
Simultaneous antigen receptor repertoire profiling and single-cell transcriptomics in T and B lymphocytes from limited clinical samplesU24AI120134 · NIAID · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2015 to 2024
$6.5M
Giant MagnetoResistive (GMR) Sensors for Measuring Influenza VaccineR01AI125197 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH, WANG, SHAN X. · 2016 to 2021
$5.0M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NIAID NIH HHS R01 AI125197NIAID NIH HHS U01 AI150741NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI090023NIAID NIH HHS U24 AI120134NIH HHS P51 OD011132NIH HHS S10 OD026799
6 · The paper itself

Abstract

The emergency use authorization of two COVID-19 mRNA vaccines in less than a year since the emergence of SARS-CoV-2, represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown. Here we used a systems biological approach to comprehensively profile the innate and adaptive immune responses in 56 healthy volunteers vaccinated with the Pfizer-BioNTech mRNA vaccine. Vaccination resulted in robust production of neutralizing antibodies (nAbs) against the parent strain and the variant of concern, B.1.351, but no induction of autoantibodies, and significant increases in antigen-specific polyfunctional CD4 and CD8 T cells after the second dose. The innate response induced within the first 2 days of booster vaccination was profoundly increased, relative to the response at corresponding times after priming. Thus, there was a striking increase in the: (i) frequency of CD14+CD16+ inflammatory monocytes; (ii) concentration of IFN-

Identifiers

PMID34013244
PMCPMC8132234
OpenAlexW3159651618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.