ArticleTurkish archives of pediatrics2021
CRP/albumin ratio: A promising marker of gram-negative bacteremia in late-onset neonatal sepsis.
Article in Turkish archives of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 17 citations in OpenAlex.
- Comparative Diagnostic Performance of RDW-to-Albumin and CRP-to-Albumin Ratios in Neonatal Sepsis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Risk Factors for Sepsis in Pediatric All During Induction Chemotherapy-Induced Neutropenia: A Single-Center Retrospective Study.Infection and drug resistance · 2026Article
- The Association Between C-Reactive Protein-to-Albumin Ratio and in-Hospital Mortality in Patients withJournal of inflammation research · 2026Article
- Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection.Archives of endocrinology and metabolism · 2025Review
- Predictive value of the preoperative C-reactive protein-to-albumin ratio for surgical site infection after percutaneous kyphoplasty: a single-center retrospective study.Frontiers in cellular and infection microbiology · 2025Article
- The clinical application of subcutaneous thoracic ratio and capillary leakage index on the occurrence of capillary leak syndrome in neonates with sepsis.Frontiers in pediatrics · 2025Article
- Relationship between C-reactive protein-albumin ratio and prognosis in pediatric patients with severe burns.PloS one · 2025Article
- Article
- Trends in Causative Organisms and Antimicrobial Resistance in Late-onset Neonatal Sepsis.Turkish archives of pediatrics · 2024Article
- Is CRP-Albumin Ratio an Indicator for Wound Infection in Children Exposed to Severe Burns? A Retrospective Cohort Study.Global pediatric health · 2024Article
- Changing trend of neonatal Ca/P/Mg status in a Chinese population.Translational pediatrics · 2023Article
- An Exciting Performance of Established and Novel Biomarkers in Diagnosing Periprosthetic Joint Infections: A Single-center Retrospective Cohort Study.Orthopaedic surgery · 2023Article
- The use of the ratio of C-reactive protein to albumin for the diagnosis of pediatric septic arthritis.Frontiers in pediatrics · 2023Article
- C-reactive protein to albumin ratio (CAR) in predicting surgical site infection (SSI) following instrumented posterior lumbar interbody fusion (PLIF).International wound journal · 2023Article
- A cross-sectional study on the correlation between blood phosphorus level with sepsis and associated prognostic factors in neonates.Annals of medicine and surgery (2012) · 2022Article
- C-reactive protein to lymphocyte ratio as a new biomarker in predicting surgical site infection after posterior lumbar interbody fusion and instrumentation.Frontiers in surgery · 2022Article
- Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates.Journal of immunology research · 2021Observational
- CRP/Albumin Has a Promising Prospect as a New Biomarker for the Diagnosis of Periprosthetic Joint Infection.Infection and drug resistance · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeonatal sepsis is a clinical condition that results in serious morbidity and mortality unless urgently diagnosed and treated. Obtaining the results of blood cultures to determine the causative agent in sepsis is a time-consuming process. The CRP/albumin ratio is an inflammatory marker that has started to be used in recent years. The aim of our study was to investigate the relationship between CRP/albumin and Gram-negative bacterial sepsis in neonates. MATERIAL AND
methodsThis study was conducted on 112 premature neonates with sepsis. The patients were divided into two groups according to culture results as Gram-negative and Gram-positive bacterial sepsis. The laboratory and demographic features of the patients were obtained from the hospital records. A receiver operating characteristic curve was plotted to evaluate the predictive value of the CRP/albumin ratio for Gram-negative sepsis.
resultsCRP/albumin was significantly higher in the Gram-negative group (p<0.001). According to the receiver operating characteristic curve, the optimal cut-off value of CRP/albumin for the prediction of Gram-negative sepsis was >35.17, which had a specificity of 97% and sensitivity of 56% (AUC=0.839; 95% CI: 0.743-0.944; p<0.001). A multivariate logistic regression analysis revealed that CRP/albumin (OR=1.082, 95% CI: 1.033-1.134, p=0.001) and absolute neutrophil count (OR=1.145, 95% CI: 1.000-1.312, p=0.049) were still associated with Gram-negative sepsis after adjustment for variables found to be statistically significant in univariate analysis and correlated with Gram-negative sepsis.
conclusionThe CRP/albumin ratio is independently related to Gram-negative sepsis in neonatal sepsis and may be useful in predicting Gram-negative bacteremia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.