Evidence map›Paper›PMID 34013207›Full record

ArticleNeuro-oncology advances

Combined

Francesco D'Amore, Farida Grinberg, Jörg Mauler, Norbert Galldiks, Ganna Blazhenets, Ezequiel Farrher, Christian Filss, Gabriele Stoffels, Felix M Mottaghy, Philipp Lohmann and 2 more

Open access · goldAbstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. HybridJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Francesco D'AmoreInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.
Farida GrinbergInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0001-8486-3126
Jörg MaulerInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0003-4937-0355
Norbert GalldiksInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0002-2485-1796
Ganna BlazhenetsInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.
Ezequiel FarrherInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0003-2902-8667
Christian FilssInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0002-9927-6335
Gabriele StoffelsInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0001-7114-1941
Felix M MottaghyCenter for Integrated Oncology (CIO), Universities of Aachen, Bonn, Cologne and Duesseldorf, Germany.ORCID https://orcid.org/0000-0002-7212-6521
Philipp LohmannInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0002-5360-046X
Nadim Jon ShahInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.ORCID https://orcid.org/0000-0002-8151-6169
Karl-Josef LangenInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.
Forschungszentrum Jülich · DEUniversity of Cologne · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiological differentiation of tumor progression (TPR) from treatment-related changes (TRC) in pretreated glioblastoma is crucial. This study aimed to explore the diagnostic value of diffusion kurtosis MRI combined with information derived from

methodsThirty-two patients with histomolecularly defined and pretreated glioblastoma suspected of having TPR were included in this retrospective study. Twenty-one patients were included in the TPR group, and 11 patients in the TRC group, as assessed by neuropathology or clinicoradiological follow-up. Three-dimensional (3D) regions of interest were generated based on increased

resultsParameters derived from diffusion MRI kurtosis maps show high diagnostic accuracy, up to 88%, for differentiating between TPR and TRC. Logistic regression revealed that the highest diagnostic accuracy of 94% (area under the curve, 0.97; sensitivity, 94%; specificity, 91%) was achieved by combining the maximum tumor-to-brain ratio of

conclusionsThe combined use of

Indexed as

amino acid PETbrain tumordiffusion kurtosis MRIpseudoprogressiontumor progression

Identifiers

PMID34013207
PMCPMC8117449
OpenAlexW3136744260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.