Evidence map›Paper›PMID 34013150›Full record

ArticleResearch and practice in thrombosis and haemostasis2021

Deep learning detects and visualizes bleeding events in electronic health records.

Jannik S Pedersen, Martin S Laursen, Thiusius Rajeeth Savarimuthu, Rasmus Søgaard Hansen, Anne Bryde Alnor, Kristian Voss Bjerre, Ina Mathilde Kjær, Charlotte Gils, Anne-Sofie Faarvang Thorsen, Eline Sandvig Andersen and 4 more

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Natural Language Processing andJMIR medical informatics · 2025
    Article
  5. Artificial intelligence in clinical thrombosis and hemostasis: A review.Research and practice in thrombosis and haemostasis · 2025
    Review
  6. Prediction model for major bleeding in anticoagulated patients with cancer-associated venous thromboembolism using machine learning and natural language processing.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Observational
  7. Artificial intelligence: revolutionizing robotic surgery: review.Annals of medicine and surgery (2012) · 2024
    Review
  8. Article
  9. Deep Learning in Hematology: From Molecules to Patients.Clinical hematology international · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jannik S PedersenThe Maersk Mc-Kinney Moller Institute University of Southern Denmark Odense Denmark.
Martin S LaursenThe Maersk Mc-Kinney Moller Institute University of Southern Denmark Odense Denmark.
Thiusius Rajeeth SavarimuthuThe Maersk Mc-Kinney Moller Institute University of Southern Denmark Odense Denmark.
Rasmus Søgaard HansenDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.
Anne Bryde AlnorDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.
Kristian Voss BjerreDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.
Ina Mathilde KjærDepartment of Clinical Biochemistry and Immunology Lillebaelt Hospital Denmark.
Charlotte GilsDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.
Anne-Sofie Faarvang ThorsenDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.
Eline Sandvig AndersenDepartment of Clinical Biochemistry and Immunology Lillebaelt Hospital Denmark.
Cathrine Brødsgaard NielsenDepartment of Gastroenterology Odense University Hospital Odense Denmark.
Lou-Ann Christensen AndersenDepartment of Ophthalmology Odense University Hospital Odense Denmark.
Søren Andreas JustDepartment of Medicine Odense University Hospital Svendborg Denmark.
Pernille Just VinholtDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBleeding is associated with a significantly increased morbidity and mortality. Bleeding events are often described in the unstructured text of electronic health records, which makes them difficult to identify by manual inspection.

objectivesTo develop a deep learning model that detects and visualizes bleeding events in electronic health records. PATIENTS/

methodsThree hundred electronic health records with

resultsOn a balanced test set of 1178   sentences, the best-performing deep learning model achieved a sensitivity of 0.90, specificity of 0.90, and negative predictive value of 0.90. On a test set consisting of 700 notes, of which 49 were positive for bleeding, the model achieved a note-level sensitivity of 1.00, specificity of 0.52, and negative predictive value of 1.00. By using a sentence-level model on a note level, the model can explain its predictions by visualizing the exact sentence in a note that contains information regarding bleeding. Moreover, we found that the model performed consistently well across different types of bleedings.

conclusionsA deep learning model can be used to detect and visualize bleeding events in the free text of electronic health records. The deep learning model can thus facilitate systematic assessment of bleeding risk, and thereby optimize patient care and safety.

Indexed as

decision support systems (clinical)deep learningelectronic health recordhemorrhageinternational classification of diseasesmachine learning

Identifiers

PMID34013150
PMCPMC8114029

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.