ArticleInternational journal of surgery protocols2021
Pre-Emptive Endoluminal Negative Pressure Therapy at the Anastomotic Site in Minimally Invasive Transthoracic Esophagectomy (the preSPONGE Trial): Study Protocol for a Multicenter Randomized Controlled Trial.
Article in International journal of surgery protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Improved Clinical Outcomes in Anastomotic Leak Management Using Preemptive Endoscopic Vacuum Therapy After Esophagectomy.Annals of surgical oncology · 2026Article
- Endoscopic vacuum therapy for gastrointestinal transmural defects: clinical outcomes and treatment implications: a retrospective study from Korea.Ewha medical journal · 2026Article
- Endoscopic Vacuum Therapy for Anastomotic Leakage After Distal Gastrectomy in a Renal Transplant Patient: A Case Study.The American journal of case reports · 2025Article
- Diagnostic Value of Postsurgical Endoscopy.Visceral medicine · 2025Review
- Endoscopic vacuum therapy for gastrointestinal transmural defects: a literature review.Clinical endoscopy · 2025Review
- Endoscopic negative-pressure treatment : From management of complications to pre-emptive active reflux drainage in abdomino-thoracic esophageal resection-A new safety concept for esophageal surgery.Chirurgie (Heidelberg, Germany) · 2025Article
- VAC-Stent in the Treatment of Post-Esophagectomy Anastomotic Leaks: A New "Kid on the Block" Who Marries the Best of Old Techniques-A Review.Journal of clinical medicine · 2024Review
- [Endoscopic negative pressure treatment : From management of complications to pre-emptive active reflux drainage in abdominothoracic esophageal resection-A new safety concept for esophageal surgery].Chirurgie (Heidelberg, Germany) · 2023Article
- Factors Influencing Postoperative Complications Following Minimally Invasive Ivor Lewis Esophagectomy: A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- The VACStent trial: combined treatment of esophageal leaks by covered stent and endoscopic vacuum therapy.Surgical endoscopy · 2023Article
- Preemptive endoluminal vacuum therapy with the VACStent-A pilot study to reduce anastomotic leakage after Ivor Lewis hybrid esophagectomy.Frontiers in surgery · 2023Article
- Adequate Management of Postoperative Complications after Esophagectomy: A Cornerstone for a Positive Outcome.Cancers · 2022Review
- Endoscopic vacuum therapy in the upper gastrointestinal tract: when and how to use it.Langenbeck's archives of surgery · 2022Review
- Endoscopic Management for Post-Surgical Complications after Resection of Esophageal Cancer.Cancers · 2022Review
- Surgical Therapy of Esophageal Adenocarcinoma-Current Standards and Future Perspectives.Cancers · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnastomotic leakage (AL) accounts for a significant proportion of morbidity following oesophagectomy. Endoluminal negative pressure (ENP) therapy via a specifically designed polyurethane foam (EsoSponge METHODS AND ANALYSIS: The study design is a prospective, multi-centre, two-arm, parallel-group, randomised controlled trial and will be conducted in two phases. Phase one is a randomised feasibility and safety pilot trial involving 40 consecutive patients. After definitive sample size calculation, additional patients will be included accordingly during phase two. The primary outcome of the study will be the postoperative length of hospitalization until reaching previously defined "fit for discharge criteria". Secondary outcomes will include postoperative morbidity, mortality and postoperative AL-rates based on 90-day follow-up. A confirmatory analysis based on intention-to-treat will be performed. ETHICS AND DISSEMINATION: The ethics committee of the University of Zurich approved this study (2019-00562), which has been registered with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.