Evidence map›Paper›PMID 34013106›Full record

ArticleKidney international reports2021

A Systematic Review of Scope and Consistency of Outcome Measures for Physical Fitness in Chronic Kidney Disease Trials.

Dev K Jegatheesan, Richard Modderman, Rathika Krishnasamy, Allison Tong, Jeff S Coombes, Andrea K Viecelli, David W Johnson, Nicole Isbel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Improving Physical Functioning for People on Long-Term Dialysis: What Does the Evidence Show?Clinical journal of the American Society of Nephrology : CJASN · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dev K JegatheesanDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.
Richard ModdermanDepartment of Physiotherapy, Princess Alexandra Hospital, Woolloongabba, Australia.
Rathika KrishnasamyCentre for Kidney Disease Research, The University of Queensland, St. Lucia, Australia.
Allison TongSydney School of Public Health, The University of Sydney, Sydney, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Sciences, The University of Queensland, St. Lucia, Australia.
Andrea K ViecelliDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.
David W JohnsonDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.
Nicole IsbelDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.
The University of Queensland · AUPrincess Alexandra Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionImpaired physical fitness is prevalent in people with chronic kidney disease (CKD), associating with an increased risk of mortality, falls, and hospitalization. A plethora of physical fitness outcomes have been reported in randomized trials. This study aimed to assess the scope and consistency of physical fitness outcomes and outcome measures reported in trials in CKD.

methodsA systematic review of randomized trials reporting physical fitness outcomes in adults with CKD (not requiring kidney replacement therapy) receiving hemodialysis (HD) or peritoneal dialysis and kidney transplant recipients was conducted. Studies were identified from MEDLINE, Embase, and the Cochrane Library from 2000 to 2019. The scope, frequency, and characteristics of outcome measures were categorized and analyzed.

resultsFrom 111 trials, 87 tests/measurements were used to evaluate 30 outcomes measures that reported on 23 outcomes, categorized into five domains of physical fitness: neuromuscular fitness (reported in 76% of trials), exercise capacity (64%), physiological-metabolic (49%), body composition (36%), and cardiorespiratory fitness (30%). Neuromuscular fitness was examined by 37 tests/measurements including the physical function component of questionnaires (27%), one-repetition maximum (9%), and hand-grip strength (9%). Outcome measures were assessed by lab-based (58% of all trials), field-based (31%), and patient-reported measures (11%), and commonly evaluated at 12 (30%), 26 (23%) and 52 weeks (10%), respectively.

conclusionThere is large heterogeneity in the reporting of physical fitness outcomes, with inconsistencies particularly in the definitions of outcome measures. Standardization in the assessment of physical fitness will likely improve the comparability of trial outcomes and enhance clinical recommendations.

Indexed as

exercisekidney diseaseoutcomesphysical fitnessrandomized controlled trials

Identifiers

PMID34013106
PMCPMC8116757
OpenAlexW3132401820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.