ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Retinal imaging demonstrates reduced capillary density in clinically unimpaired
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults.Translational vision science & technology · 2026Article
- Apolipoprotein E ε4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice.Communications biology · 2025Article
- Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans.Science translational medicine · 2024Article
- Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review.Acta neuropathologica communications · 2024Review
- Brain Microvascular Pericyte Pathology Linking Alzheimer's Disease to Diabetes.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments.Bioengineering (Basel, Switzerland) · 2024Review
- Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023Review
- The Association ofJournal of clinical medicine · 2023Article
- APOE ε4 Gene Carriers Demonstrate Reduced Retinal Capillary Densities in Asymptomatic Older Adults.Journal of clinical medicine · 2023Article
- A model eye for fluorescent characterization of retinal cultures and tissues.Scientific reports · 2023Article
- Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.Neurobiology of aging · 2023Article
- Beta-Amyloid Peptide in Tears: An Early Diagnostic Marker of Alzheimer's Disease Correlated with Choroidal Thickness.International journal of molecular sciences · 2023Article
- Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment: The NORFACE cohort.Frontiers in neuroscience · 2023Article
- Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease.CNS neuroscience & therapeutics · 2022Article
- ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.Molecular neurodegeneration · 2022Review
- Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.Ophthalmology. Retina · 2022Article
Corrections and comments
- Erratum issuedErratum.2021
Authors and funding
15 authors at 4 institutions in 1 country.
Fanny M ElahiDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Senyo B AshimateyDepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USA.
Daniel J BennettDepartment of Neurology Division of Neuroimmunology and Glial Biology Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Samantha M WaltersDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Renaud La JoieDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Xuejuan JiangDepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USA.
Amy WolfDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Yann CobigoDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Adam M StaffaroniDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Howie J RosenDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Bruce L MillerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Gil D RabinoviciDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Joel H KramerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Ari J GreenDepartment of Neurology Division of Neuroimmunology and Glial Biology Weill Institute for Neurosciences San Francisco University of California San Francisco California USA.
Amir H KashaniDepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USA.
University of California, San Francisco · USUniversity Memory and Aging Center · USUniversity of Southern California · USG1 Therapeutics (United States) · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MMultidimensional Assessment of Brain Health as A Marker of Dementia Risk and ResilienceR01AG066524 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KASHANI, AMIR H, RAMACHANDRAN, VASAN S · 2020 to 2024
$9.7MMechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3MBiological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3MImaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel DiseaseUH3NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2018 to 2020
$4.3MNovel imaging and endothelial biomarkers of small vessel cerebrovascular diseaseUH3NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DECARLI, CHARLES, KRAMER, JOEL H · 2018 to 2020
$3.5MAssessment of Retinal Capillary Density, Morphology and Function in Retinal Vascular Disease Using Novel OCT Angiography Based MetricsR01EY030564 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H · 2019 to 2024
$3.5MEffects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2MEarly Age-of-Onset AD: Clinical Heterogeneity and Network DegenerationR01AG045611 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RABINOVICI, GIL DAN · 2014 to 2018
$3.1MCSRD VA IK2 CX002180NEI NIH HHS R01 EY030564NIA NIH HHS K23 AG061253NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG066546NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG045611NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG066524NIA NIH HHS RF1 AG032289NIA NIH HHS U24 AG021886NINDS NIH HHS UF1 NS100614NINDS NIH HHS UH2 NS100608NINDS NIH HHS UH2 NS100614NINDS NIH HHS UH3 NS100608NINDS NIH HHS UH3 NS100614
Abstract
introductionApolipoprotein E (
methodsWe collected retinal optical coherence tomography angiography, cognitive testing, and brain imaging in research participants and built statistical models to test genotype-phenotype associations.
resultsOur analyses demonstrate lower retinal capillary densities in early disease, in cognitively normal DISCUSSION: These results suggest that
Indexed as
Alzheimer's diseaseapolipoprotein E ε4capillary rarefactionpreclinical biomarkerpreclinical diseasevascular contributions to Alzheimer's disease
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.