Evidence map›Paper›PMID 34012972›Full record

ArticleFrontiers in medicine2021

Age, Initial Central Retinal Thickness, and OCT Biomarkers Have an Influence on the Outcome of Diabetic Macular Edema Treated With Ranibizumab- Tri-center 12-Month Treat-and-Extend Study.

Chun-Ting Lai, Yi-Ting Hsieh, Chun-Ju Lin, Jia-Kang Wang, Chih-Ying Lin, Ning-Yi Hsia, Henry Bair, Huan-Sheng Chen, Chiung-Yi Chiu, Shao-Wei Weng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Risk of excessive macular thinning in diabetic macular edema with ellipsoid zone disruption treated with anti-VEGF: 2-year real-world evidence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chun-Ting LaiDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Yi-Ting HsiehDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Ju LinDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Jia-Kang WangDepartment of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Chih-Ying LinDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Ning-Yi HsiaDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Henry BairDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Huan-Sheng ChenAn-Shin Dialysis Center, NephroCare Ltd., Fresenius Medical Care, Taichung, Taiwan.
Chiung-Yi ChiuDepartment of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Shao-Wei WengDepartment of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Asia University · TWChina Medical University · TWFar Eastern Memorial Hospital · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agecentral retinal thicknessdiabetic macular edemaOCT biomarkersranibizumabtreat-and-extend regimen 5

Identifiers

PMID34012972
PMCPMC8126636
OpenAlexW3157063226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.