ArticleTranslational lung cancer research2021
Blood transfusions may adversely affect survival outcomes of patients with lung cancer: a systematic review and meta-analysis.
Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Erythrocyte Transfusion as an Independent Predictor of Survival but Not Immune-Related Toxicity in Nivolumab-Treated Metastatic NSCLC: A Multicenter Cohort.Medicina (Kaunas, Lithuania) · 2026Article
- Major Postoperative Complications and Survival After Lung Cancer Resection in Patients Aged ≥80 Years: Risk Factor Analysis.Current oncology (Toronto, Ont.) · 2026Article
- Single Cancer Center Experience on Patient Blood Management Eligibility in Oncological Surgery.Journal of clinical medicine · 2026Article
- Article
- Bleeding and long-term survival after lung resections: nationwide observational cohort study.Journal of thoracic disease · 2024Article
- Review
- Comparison of transfusion rates between robotic- and video-assisted lobectomy: a propensity score matching analysis.Journal of robotic surgery · 2023Article
- Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite common use in clinical practice, the impact of blood transfusions on prognosis among patients with lung cancer remains unclear. The purpose of the current study is to perform an updated systematic review and meta-analysis to evaluate the influence of blood transfusions on survival outcomes of lung cancer patients.
methodsWe searched PubMed, Embase, Cochrane Library, and Ovid MEDLINE for publications illustrating the association between blood transfusions and prognosis among people with lung cancer from inception to November 2019. Overall survival (OS) and disease-free survival (DFS) were the outcomes of interest. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were computed using the random-effects model. Study heterogeneity was evaluated with the I
resultsWe included 23 cohort studies with 12,175 patients (3,027 cases and 9,148 controls) for meta-analysis. Among these records, 22 studies investigated the effect of perioperative transfusions, while one examined that of transfusions during chemotherapy. Two studies suggested the possible dose-dependent effect in accordance with the number of transfused units. In pooled analyses, blood transfusions deleteriously influenced both OS (HR=1.35, 95% CI: 1.14-1.61, P<0.001, I
conclusionsBlood transfusions were associated with decreased survival of patients with lung cancer.
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