ArticleNanotechnology reviews2020
Degradation modeling of poly-l-lactide acid (PLLA) bioresorbable vascular scaffold within a coronary artery.
Article in Nanotechnology reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Long-term follow-up results of percutaneous closure of atrial septal defect with a novel biodegradable poly-L-lactic acid device in pediatrics: data from a prospective, single-center trial.Frontiers in cardiovascular medicine · 2026Article
- Additive Manufacturing of Polymeric Bioresorbable Stents: A Mechanical Performance Perspective.Biomaterials research · 2026Review
- Improved vascular response to a novel polymeric blend PLLA/PLGA coronary scaffold material: preclinical study.Scientific reports · 2025Article
- PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles.Journal of functional biomaterials · 2024Article
- A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent.Medical & biological engineering & computing · 2024Article
- Assessment of degradability and endothelialization of modified poly L-lactic acid (PLLA) atrial septal defect (ASD) occluders over time in vivo.Journal of cardiothoracic surgery · 2023Article
- Load-sharing characteristics of stenting and post-dilation in heavily calcified coronary artery.Scientific reports · 2023Article
- Load-sharing characteristics of stenting and post-dilation in heavily calcified coronary artery.Research square · 2023Article
- The endothelium permeability after bioresorbable scaffolds implantation caused by the heterogeneous expression of tight junction proteins.Materials today. Bio · 2022Article
- Upper Airway Flow Dynamics in Obstructive Sleep Apnea Patients with Various Apnea-Hypopnea Index.Life (Basel, Switzerland) · 2022Article
- Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications.Polymers · 2022Review
- Analysis of Causes and Results of Fetal Growth in Utero Caused by Genetic Factors Detected by Ultrasound.Contrast media & molecular imaging · 2022Article
- InSilc Computational Tool forComputational and mathematical methods in medicine · 2022Article
- The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents.Micromachines · 2021Review
- Application ofFrontiers in medical technology · 2021Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
In this work, a strain-based degradation model was implemented and validated to better understand the dynamic interactions between the bioresorbable vascular scaffold (BVS) and the artery during the degradation process. Integrating the strain-modulated degradation equation into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both strut thinning and discontinuity of the stent struts within an artery were captured and visualized. The predicted results in terms of mass loss and fracture locations were validated by the documented experimental observations. In addition, results suggested that the heterogeneous degradation of the stent depends on its strain distribution following deployment. Degradation is faster at the locations with higher strains and resulted in the strut thinning and discontinuity, which contributes to the continuous mass loss, and the reduced contact force between the BVS and artery. A nonlinear relationship between the maximum principal strain of the stent and the fracture time was obtained, which could be transformed to predict the degradation process of the BVS in different mechanical environments. The developed computational model provided more insights into the degradation process, which could complement the discrete experimental data for improving the design and clinical management of the BVS.
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Registered trials
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