Evidence map›Paper›PMID 34012554›Full record

ArticleNeuropsychiatric electrophysiology2015

Robert J Thoma, Jason Long, Mollie Monnig, Ronald A Yeo, Helen Petropoulos, Charles Gasparovic, Jessica Pommy, Paul G Mullins

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric electrophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Robert J ThomaDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Jason LongDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Mollie MonnigDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Ronald A YeoDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Helen PetropoulosDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Charles GasparovicDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Jessica PommyDepartments of Psychiatry and Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Paul G MullinsBangor Imaging Unit, School of Psychology, Bangor University, Adeilad Brigantia, Penrallt Road, Bangor LL57 2ASGwynedd, UK.
University of New Mexico · USBangor University · GBMind Research Network · US

Funding

NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI JUNG, REX · 2008 to 2011
$9.4M
Adolescent Neurodevelopment and AlcoholR21AA017313 · NIAAA · UNIVERSITY OF NEW MEXICO · PI THOMA, ROBERT J · 2007 to 2008
$767k
Brain and Behavioral Impairment in Alcohol Dependence and SchizophreniaK23AA016544 · NIAAA · UNIVERSITY OF NEW MEXICO · PI THOMA, ROBERT J · 2006 to 2010
$683k
NCRR NIH HHS P20 RR021938NIAAA NIH HHS K23 AA016544NIAAA NIH HHS R21 AA017313
6 · The paper itself

Abstract

backgroundImpairment in auditory sensory gating (ASG) has been documented in alcohol dependence [1]. Likewise, it has been shown that ASG becomes abnormal during alcohol administration in otherwise healthy individuals [2]. Patterns of gating abnormality associated with alcohol use are likely associated with an alcohol responsive neurochemical like glutamate (Glu), particularly since it is well-established that alcohol affects NMDA receptors and that glutamatergic functioning is abnormal in both acute alcohol use and in alcohol dependence [3]. Hence, a link between Glu metabolite levels and ASG was hypothesized. It was first hypothesized that Glu and ASG abnormality would be found in groups with alcohol dependence. A second hypothesis was that across groups, greater Glu would predict reduced ASG.

methodsGroups were comprised of healthy, non-drinking controls (Controls,

resultsUnivariate MANOVAs controlling for age and gender revealed a significant effect for group on Glu and ASG, such that ASG ratios were significantly elevated, implying weakened gating. Glu concentration was reduced in AUD-current relative to the other two groups. Further analysis revealed that when additionally controlling for the group effect, reduced Glu predicted increasing impairment in ASG.

conclusionsThe overall results were consistent with the hypothesis that differences in Glu metabolite levels associated with alcohol dependence result in impaired ASG.

Indexed as

1H-MRSAuditory event related potentialAuditory sensory gatingMagnetoencephalographyMEGPaired click paradigmProton magnetic resonance spectroscopy

Identifiers

PMID34012554
PMCPMC8130891
OpenAlexW2213168349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.